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2YPU

human insulin degrading enzyme E111Q in complex with inhibitor compound 41367

Replaces:  2YB3
Summary for 2YPU
Entry DOI10.2210/pdb2ypu/pdb
DescriptorINSULIN-DEGRADING ENZYME, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, ... (4 entities in total)
Functional Keywordshydrolase, m16a metalloprotease
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm: P14735
Total number of polymer chains2
Total formula weight230000.76
Authors
Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.-J. (deposition date: 2012-11-01, release date: 2012-11-28, Last modification date: 2023-12-20)
Primary citationCharton, J.,Gauriot, M.,Guo, Q.,Hennuyer, N.,Marechal, X.,Dumont, J.,Hamdane, M.,Pottiez, V.,Landry, V.,Sperandio, O.,Flipo, M.,Buee, L.,Staels, B.,Leroux, F.,Tang, W.-J.,Deprez, B.,Deprez-Poulain, R.
Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis
Eur J Med Chem, 79C:184-, 2014
Cited by
PubMed: 24735644
DOI: 10.1016/J.EJMECH.2014.04.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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