6EDS

Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63

Summary for 6EDS

Entry DOI	10.2210/pdb6eds/pdb
Related	2G49 4LTE 6BYZ
Descriptor	Insulin-degrading enzyme, Glucagon, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol, ... (6 entities in total)
Functional Keywords	insulin, glucagon, diabetes, exo-site, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	235209.98
Authors	Tan, G.A.,Seeliger, M.A.,Maianti, J.P.,Liu, D.R.,Welsh, A.J. (deposition date: 2018-08-10, release date: 2019-04-03, Last modification date: 2023-10-11)
Primary citation	Maianti, J.P.,Tan, G.A.,Vetere, A.,Welsh, A.J.,Wagner, B.K.,Seeliger, M.A.,Liu, D.R. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat.Chem.Biol., 15:565-574, 2019 Cited by PubMed: 31086331 DOI: 10.1038/s41589-019-0271-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.18071730876 Å)

Structure validation