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5CJO

Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin

Summary for 5CJO
Entry DOI10.2210/pdb5cjo/pdb
DescriptorInsulin-degrading enzyme, FAB Heavy chain with engineered elbow, FAB light chain, ... (6 entities in total)
Functional Keywordshydrolase, fab, elbow-engineer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight166314.66
Authors
liang, w.g.,bailey, L.,tang, w.j. (deposition date: 2015-07-14, release date: 2016-07-20, Last modification date: 2023-09-27)
Primary citationBailey, L.J.,Sheehy, K.M.,Dominik, P.K.,Liang, W.G.,Rui, H.,Clark, M.,Jaskolowski, M.,Kim, Y.,Deneka, D.,Tang, W.J.,Kossiakoff, A.A.
Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
Cited by
PubMed: 29273204
DOI: 10.1016/j.jmb.2017.12.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.287 Å)
Structure validation

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