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5CJO

Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin

Functional Information from GO Data
ChainGOidnamespacecontents
a0005179molecular_functionhormone activity
a0005576cellular_componentextracellular region
A0001618molecular_functionvirus receptor activity
A0004175molecular_functionendopeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005777cellular_componentperoxisome
A0005782cellular_componentperoxisomal matrix
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0008286biological_processinsulin receptor signaling pathway
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010815biological_processbradykinin catabolic process
A0010992biological_processubiquitin recycling
A0016323cellular_componentbasolateral plasma membrane
A0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
A0030163biological_processprotein catabolic process
A0032092biological_processpositive regulation of protein binding
A0042277molecular_functionpeptide binding
A0042447biological_processhormone catabolic process
A0042803molecular_functionprotein homodimerization activity
A0043171biological_processpeptide catabolic process
A0043559molecular_functioninsulin binding
A0045732biological_processpositive regulation of protein catabolic process
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050435biological_processamyloid-beta metabolic process
A0051603biological_processproteolysis involved in protein catabolic process
A0070062cellular_componentextracellular exosome
A0097242biological_processamyloid-beta clearance
A0150094biological_processamyloid-beta clearance by cellular catabolic process
A1901142biological_processinsulin metabolic process
A1901143biological_processinsulin catabolic process
A1903715biological_processregulation of aerobic respiration
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue EPE A 2001
ChainResidue
AARG839
AALA840
AASN841
AGLY842
AARG893
ASER913

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 2002
ChainResidue
aTYR14
AHIS108
AHIS112
AGLU189

Functional Information from PROSITE/UniProt
site_idPS00262
Number of Residues15
DetailsINSULIN Insulin family signature. CCTSiCSlyqLenyC
ChainResidueDetails
aCYS6-CYS20

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR212-HIS218
LTYR194-HIS200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390
ChainResidueDetails
AGLN111

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57
ChainResidueDetails
AHIS108
AHIS112
AGLU189

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: in the exosite
ChainResidueDetails
AHIS336

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:18986166
ChainResidueDetails
ALEU359

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P35559
ChainResidueDetails
AARG429
AASP895

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7
ChainResidueDetails
ALYS192
ALYS697

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PDB entries from 2024-07-24

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