6MQ3

Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocycle Inhibitor 63

Summary for 6MQ3

• Entry DOI: 10.2210/pdb6mq3/pdb
• Related: 2G49 4LTE 6BYZ 6EDS
• Descriptor: Insulin-degrading enzyme, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID (3 entities in total)
• Functional Keywords: insulin, glucagon, diabetes, exo-site, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 227847.97

Authors

Tan, G.A.,Seeliger, M.A.,Welsh, A.J.,Maianti, J.P.,Liu, D.R. (deposition date: 2018-10-09, release date: 2019-04-03, Last modification date: 2023-10-11)

• Primary citation: Maianti, J.P.,Tan, G.A.,Vetere, A.,Welsh, A.J.,Wagner, B.K.,Seeliger, M.A.,Liu, D.R.; Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.; Nat.Chem.Biol., 15:565-574, 2019; PubMed: 31086331; DOI: 10.1038/s41589-019-0271-0

Experimental method

X-RAY DIFFRACTION (3.56914708689 Å)