6LFO
| Cryo-EM structure of a class A GPCR monomer | 分子名称: | C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. | 登録日 | 2019-12-03 | 公開日 | 2020-09-02 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
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7YU3
| Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Akasaka, H, Shihoya, W, Nureki, O. | 登録日 | 2022-08-16 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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8IW1
| Cryo-EM structure of the PEA-bound mTAAR9-Golf complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(olf) subunit alpha, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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7WU4
| Cryo-EM structure of the adhesion GPCR ADGRF1 in complex with miniGi | 分子名称: | Adhesion G-protein coupled receptor F1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Qu, X, Qiu, N, Wang, M, Zhao, Q, Wu, B. | 登録日 | 2022-02-05 | 公開日 | 2022-04-27 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Nature, 604, 2022
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8IKG
| Cryo-EM structure of human receptor with G proteins | 分子名称: | 3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Shen, S.Y, Shao, Z.H. | 登録日 | 2023-02-28 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of human receptor with G proteins To Be Published
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7X9B
| Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-03-15 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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7EXD
| Lasmiditan-bound serotonin 1F (5-HT1F) receptor-Gi protein complex | 分子名称: | 2,4,6-tris(fluoranyl)-N-[6-(1-methylpiperidin-4-yl)carbonylpyridin-2-yl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Huang, S, Xu, P, Jiang, Y, Xu, H.E. | 登録日 | 2021-05-27 | 公開日 | 2021-08-04 | 最終更新日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT 1F -G protein complex. Cell Res., 31, 2021
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7EW1
| Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 5 in complex with Gi protein | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Y, Jia, G.W, Shao, Z.H, Su, Z.M. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
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8IC0
| Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer | 分子名称: | C-X-C chemokine receptor type 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Ishimoto, N, Park, J.H, Park, S.Y. | 登録日 | 2023-02-10 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Structural basis of CXC chemokine receptor 1 ligand binding and activation. Nat Commun, 14, 2023
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2XNS
| Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14 | 分子名称: | GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, GUANOSINE-5'-DIPHOSPHATE, REGULATOR OF G-PROTEIN SIGNALING 14, ... | 著者 | Bosch, D, Sammond, D.W, Butterfoss, G.L, Machius, M, Siderovski, D.P, Kuhlman, B. | 登録日 | 2010-08-05 | 公開日 | 2011-06-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | Computational Design of the Sequence and Structure of a Protein-Binding Peptide. J.Am.Chem.Soc., 133, 2011
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7EW0
| Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | 分子名称: | 5-[3-[(1~{S})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{H}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Y, Jia, G.W, Su, Z.M, Shao, Z.H. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
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7VH0
| MT2-remalteon-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Melatonin receptor type 1B, ... | 著者 | Wang, Q.G, Lu, Q.Y. | 登録日 | 2021-09-20 | 公開日 | 2022-03-02 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Nat Commun, 13, 2022
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8WCA
| Cryo-EM structure of the PEA-bound hTAAR1-Gs complex | 分子名称: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | 登録日 | 2023-09-11 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186, 2023
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8IW4
| Cryo-EM structure of the SPE-bound mTAAR9-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8JIL
| Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | 登録日 | 2023-05-26 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol.Cell, 83, 2023
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9AXF
| Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ... | 著者 | Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
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6DDE
| Mu Opioid Receptor-Gi Protein Complex | 分子名称: | DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I. | 登録日 | 2018-05-10 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the mu-opioid receptor-Giprotein complex. Nature, 558, 2018
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6DDF
| Mu Opioid Receptor-Gi Protein Complex | 分子名称: | DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Koehl, A, Hu, H, Maeda, S, Manglik, A, Kobilka, B.K, Skiniotis, G, Weis, W.I. | 登録日 | 2018-05-10 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the mu-opioid receptor-Giprotein complex. Nature, 558, 2018
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8GCM
| Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein | 分子名称: | (5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Huang, S.M, Xiong, M.Y, Liu, L, Mu, J, Sheng, C, Sun, J. | 登録日 | 2023-03-02 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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8GDC
| Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Shenming, H, Mengyao, X, Lei, L, Yang, D, Shiyi, G, Jinpeng, S. | 登録日 | 2023-03-03 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths. Proc.Natl.Acad.Sci.USA, 120, 2023
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6LFM
| Cryo-EM structure of a class A GPCR | 分子名称: | C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. | 登録日 | 2019-12-03 | 公開日 | 2020-09-02 | 最終更新日 | 2020-09-16 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
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7EB2
| Cryo-EM structure of human GABA(B) receptor-Gi protein complex | 分子名称: | (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ... | 著者 | Shen, C, Mao, C, Xu, C, Jin, N, Zhang, H, Shen, D, Shen, Q, Wang, X, Hou, T, Rondard, P, Chen, Z, Pin, J, Zhang, Y, Liu, J. | 登録日 | 2021-03-08 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of GABA B receptor-G i protein coupling. Nature, 594, 2021
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7E9G
| Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 | 分子名称: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, DN13, ... | 著者 | Lin, S, Han, S, Zhao, Q, Wu, B. | 登録日 | 2021-03-04 | 公開日 | 2021-06-23 | 最終更新日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4. Nature, 594, 2021
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7RKM
| Structure of CX3CL1-US28-Gi-scFv16 in C-state | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | 著者 | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | 登録日 | 2021-07-22 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins Sci Adv, 8, 2022
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7YU6
| Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state2 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Akasaka, H, Shihoya, W, Nureki, O. | 登録日 | 2022-08-16 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of the active G i -coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. Nat Commun, 13, 2022
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