8GCM

Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

Summary for 8GCM

• Entry DOI: 10.2210/pdb8gcm/pdb
• EMDB information: 29935
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 167929.72

Authors

Huang, S.M.,Xiong, M.Y.,Liu, L.,Mu, J.,Sheng, C.,Sun, J. (deposition date: 2023-03-02, release date: 2024-01-03, Last modification date: 2024-01-10)

• Primary citation: Huang, S.M.,Xiong, M.Y.,Liu, L.,Mu, J.,Wang, M.W.,Jia, Y.L.,Cai, K.,Tie, L.,Zhang, C.,Cao, S.,Wen, X.,Wang, J.L.,Guo, S.C.,Li, Y.,Qu, C.X.,He, Q.T.,Cai, B.Y.,Xue, C.,Gan, S.,Xie, Y.,Cong, X.,Yang, Z.,Kong, W.,Li, S.,Li, Z.,Xiao, P.,Yang, F.,Yu, X.,Guan, Y.F.,Zhang, X.,Liu, Z.,Yang, B.X.,Du, Y.,Sun, J.P.; Single hormone or synthetic agonist induces G s /G i coupling selectivity of EP receptors via distinct binding modes and propagating paths.; Proc.Natl.Acad.Sci.USA, 120:e2216329120-e2216329120, 2023; PubMed: 37478163; DOI: 10.1073/pnas.2216329120

Experimental method

ELECTRON MICROSCOPY (3.5 Å)