Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8GCM

Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440445.11UniProt (P63096)
Pfam (PF00503)
Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35839418.11UniProt (P62873)
Pfam (PF00400)
Homo sapiens (human)Transducin beta chain 1
3C
(C)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)
Homo sapiens (human)G gamma-I
4D
(E)
scFv16polymer25026610.61Homo sapiens (human)
5E
(R)
Prostaglandin E2 receptor EP4 subtypepolymer48853173.31UniProt (P35408)
Pfam (PF00001)
Homo sapiens (human)PGE receptor EP4 subtype,PGE2 receptor EP4 subtype,Prostanoid EP4 receptor
6F
(R)
(5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-onenon-polymer421.51Chemie (YX9)
Sequence modifications
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Ala 203Gly 203conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight167508.2
Non-Polymers*Number of molecules1
Total formula weight421.5
All*Total formula weight167929.7
*Water molecules are not included.

239149

PDB entries from 2025-07-23

PDB statisticsPDBj update infoContact PDBjnumon