7WU4

Cryo-EM structure of the adhesion GPCR ADGRF1 in complex with miniGi

Summary for 7WU4

• Entry DOI: 10.2210/pdb7wu4/pdb
• EMDB information: 32819
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: adhesion gpcr, adgrf1, g protein, complex, signal transduction, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 149662.66

Authors

Qu, X.,Qiu, N.,Wang, M.,Zhao, Q.,Wu, B. (deposition date: 2022-02-05, release date: 2022-04-27, Last modification date: 2022-05-11)

• Primary citation: Qu, X.,Qiu, N.,Wang, M.,Zhang, B.,Du, J.,Zhong, Z.,Xu, W.,Chu, X.,Ma, L.,Yi, C.,Han, S.,Shui, W.,Zhao, Q.,Wu, B.; Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1.; Nature, 604:779-785, 2022; PubMed: 35418679; DOI: 10.1038/s41586-022-04580-w

Experimental method

ELECTRON MICROSCOPY (3.4 Å)