2XNS

Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14

Summary for 2XNS

Entry DOI	10.2210/pdb2xns/pdb
Related	1KJY 1Y3A 2GTP 2IK8
Descriptor	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, REGULATOR OF G-PROTEIN SIGNALING 14, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	hydrolase-peptide complex, adp-ribosylation, arginine finger, gtp-binding, lipoprotein, nucleotide-binding, palmitate, signaling protein, transducer, protein-protein interface design, hydrolase/peptide
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	85518.16
Authors	Bosch, D.,Sammond, D.W.,Butterfoss, G.L.,Machius, M.,Siderovski, D.P.,Kuhlman, B. (deposition date: 2010-08-05, release date: 2011-06-08, Last modification date: 2023-12-20)
Primary citation	Sammond, D.W.,Bosch, D.E.,Butterfoss, G.L.,Purbeck, C.,Machius, M.,Siderovski, D.P.,Kuhlman, B. Computational Design of the Sequence and Structure of a Protein-Binding Peptide. J.Am.Chem.Soc., 133:4190-, 2011 Cited by PubMed: 21388199 DOI: 10.1021/JA110296Z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.41 Å)

Structure validation