2XNS
Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1 | polymer | 327 | 37374.6 | 2 | UniProt (P63096) Pfam (PF00503) | HOMO SAPIENS (HUMAN) | ADENYLATE CYCLASE-INHIBITING G ALPHA PROTEIN |
| 2 | C, D (C, D) | REGULATOR OF G-PROTEIN SIGNALING 14 | polymer | 40 | 4695.2 | 2 | UniProt (O43566) Pfam (PF02188) | HOMO SAPIENS | RGS14 |
| 3 | E, G (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | F, H (A, B) | S,R MESO-TARTARIC ACID | non-polymer | 150.1 | 2 | Chemie (SRT) | |||
| 5 | I, J (C, D) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 30 - 354 (UniProt: P63096)
C, D: 496 - 516 (UniProt: O43566)
| PDB | External Database | Details |
|---|---|---|
| Ser 28 | - | expression tag |
| Asn 29 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 517 | - | expression tag |
| Leu 518 | - | expression tag |
| Leu 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Asn 521 | - | expression tag |
| Glu 522 | - | expression tag |
| Glu 523 | - | expression tag |
| Val 524 | - | expression tag |
| Phe 525 | - | expression tag |
| Arg 526 | - | expression tag |
| Ala 527 | - | expression tag |
| Leu 528 | - | expression tag |
| Arg 529 | - | expression tag |
| Asp 530 | - | expression tag |
| Phe 531 | - | expression tag |
| Asp 532 | - | expression tag |
| Arg 533 | - | expression tag |
| Trp 534 | - | expression tag |
| Phe 535 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 84139.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1378.7 | |
| All* | Total formula weight | 85518.2 |
