9AXF

Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent

Summary for 9AXF

Entry DOI	10.2210/pdb9axf/pdb
EMDB information	43966
Descriptor	Extracellular calcium-sensing receptor, PHOSPHATE ION, CALCIUM ION, ... (15 entities in total)
Functional Keywords	calcium-sensing receptor, g-protein-coupled receptor, g protein, signal transduction, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	7
Total formula weight	340556.71
Authors	Zuo, H.,Park, J.,Frangaj, A.,Ye, J.,Lu, G.,Manning, J.J.,Asher, W.B.,Lu, Z.,Hu, G.,Wang, L.,Mendez, J.,Eng, E.,Zhang, Z.,Lin, X.,Grasucci, R.,Hendrickson, W.A.,Clarke, O.B.,Javitch, J.A.,Conigrave, A.D.,Fan, Q.R. (deposition date: 2024-03-06, release date: 2024-04-17)
Primary citation	Zuo, H.,Park, J.,Frangaj, A.,Ye, J.,Lu, G.,Manning, J.J.,Asher, W.B.,Lu, Z.,Hu, G.,Wang, L.,Mendez, J.,Eng, E.,Zhang, Z.,Lin, X.,Grasucci, R.,Hendrickson, W.A.,Clarke, O.B.,Javitch, J.A.,Conigrave, A.D.,Fan, Q.R. Promiscuous G-protein activation by the calcium-sensing receptor Nature, 2024 Cited by DOI: 10.1038/s41586-024-07331-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation