Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9AXF

Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(R, Q)		Extracellular calcium-sensing receptorpolymer911102864.62UniProt (P41180)
Pfam (PF01094)
Pfam (PF07562)
Pfam (PF00003)		Homo sapiens (human)CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1
2C
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1,Adenylate cyclase-stimulating G alpha proteinpolymer24628306.11UniProt (P63096)
UniProt (A0A590UJY2)
Pfam (PF00503)
UniProt (by SIFTS) (P63092)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
3D
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34838413.91UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
4E
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5F
(H)		Single-chain antibody fragment scFv16polymer29731870.61Mus musculus
6G
(N)		Nanobody Nb-35polymer16017352.51Lama glama
7H, I, J, K
(C, D, E, F)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.44In PDB
GlyTouCan (G42666HT)
8CA, DA, EA, FA, L...
(Q, R)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.28Chemie (NAG)
9GA, P
(Q, R)		CYCLOMETHYLTRYPTOPHANnon-polymer216.22Chemie (TCR)
10HA, Q
(Q, R)		PHOSPHATE IONnon-polymer95.02Chemie (PO4)
PubChem (1061)
11IA, JA, KA, LA, R...
(Q, R)		CALCIUM IONnon-polymer40.17Chemie (CA)
PubChem (271)
12MA, U
(Q, R)		3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-aminenon-polymer303.82Chemie (9IG)
PubChem (158797)
PubChem (66833828)
PubChem (6101864)
13V
(R)		Lauryl Maltose Neopentyl Glycolnon-polymer1005.21Chemie (AV0)
14NA, W, X, Y
(Q, R)		CHOLESTEROL HEMISUCCINATEnon-polymer486.74Chemie (Y01)
PubChem (16219150)
PubChem (22210610)
PubChem (65082)
PubChem (45489984)
PubChem (363416)
PubChem (60078761)
PubChem (500055)
PubChem (73440805)
PubChem (57163942)
PubChem (89891013)
PubChem (99567468)
PubChem (124427194)
PubChem (124897021)
PubChem (124897020)
PubChem (10005657)
PubChem (130340716)
PubChem (99567469)
PubChem (11969853)
PubChem (137392566)
PubChem (137496323)
PubChem (124301053)
PubChem (124302591)
PubChem (124303794)
PubChem (124421343)
PubChem (124427195)
PubChem (13301926)
PubChem (13301927)
PubChem (124914595)
PubChem (124914596)
PubChem (155804219)
PubChem (169132514)
PubChem (131705526)
PubChem (137332121)
PubChem (137496357)
PubChem (146157332)
PubChem (154929912)
PubChem (155199678)
PubChem (156327905)
PubChem (156426247)
PubChem (156516588)
PubChem (166979870)
PubChem (167024614)
PubChem (169132513)
PubChem (170117245)
PubChem (172400028)
15AA, BA, OA, PA, QA...
(R, Q)		CHOLESTEROLnon-polymer386.78Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
R, Q: 1 - 903 (UniProt: P41180)
PDBExternal DatabaseDetails
Asp 904-expression tag
Tyr 905-expression tag
Lys 906-expression tag
Asp 907-expression tag
Asp 908-expression tag
Asp 909-expression tag
Asp 910-expression tag
Lys 911-expression tag
A: 1 - 53 (UniProt: P63096)
PDBExternal DatabaseDetails
Glu 20Asp 20engineered mutation
Lys 21Arg 21engineered mutation
Gln 22Asn 22engineered mutation
Gln 24Arg 24engineered mutation
Lys 25Glu 25engineered mutation
Lys 27Gly 27engineered mutation
Gln 28Glu 28engineered mutation
Val 29Lys 29engineered mutation
Tyr 30Ala 30engineered mutation
Arg 31Ala 31engineered mutation
Ala 32Arg 32engineered mutation
Thr 33Glu 33engineered mutation
His 34Val 34engineered mutation
Arg 35Lys 35engineered mutation
Asp 42Gly 42engineered mutation
Asn 43Glu 43engineered mutation
Arg 54-linker
Ile 55-linker
Leu 56-linker
His 57-linker
Gly 58-linker
Gly 59-linker
Ser 60-linker
Gly 61-linker
Gly 62-linker
Ser 63-linker
Gly 64-linker
Gly 65-linker
Thr 66-linker
Ser 67-linker
Gly 68-linker
A: 69 - 246 (UniProt: A0A590UJY2)
PDBExternal DatabaseDetails
Asp 111Ala 92engineered mutation
Asp 114Ser 95engineered mutation
-Asn 97deletion
-Met 98deletion
-Val 99deletion
-Ile 100deletion
-Arg 101deletion
-Glu 102deletion
-Asp 103deletion
-Asn 104deletion
-Gln 105deletion
-Thr 106deletion
Asp 124Leu 115engineered mutation
Ala 224Ile 215engineered mutation
Ile 227Val 218engineered mutation
Lys 232Arg 223engineered mutation
Leu 236Gln 227engineered mutation
Gln 237Arg 228engineered mutation
Asn 239His 230engineered mutation
Glu 242Gln 233engineered mutation
Asn 244Glu 235engineered mutation
Val 246Leu 237engineered mutation
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -7-initiating methionine
Asp -6-expression tag
Tyr -5-expression tag
Lys -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Asp 0-expression tag
Lys 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight329533.5
BranchedNumber of molecules4
Total formula weight1697.6
Non-Polymers*Number of molecules34
Total formula weight9325.6
All*Total formula weight340556.7
*Water molecules are not included.

253389

PDB entries from 2026-05-13

PDB statisticsPDBj update infoContact PDBjnumon