8JIL

Cryo-EM structure of niacin bound ketone body receptor HCAR2-Gi signaling complex

Summary for 8JIL

Entry DOI	10.2210/pdb8jil/pdb
EMDB information	36317 36494 36495 36507
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (8 entities in total)
Functional Keywords	complex, agonist, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	162597.61
Authors	Zhao, C.,Tian, X.W.,Liu, Y.,Cheng, L.,Yan, W.,Shao, Z.H. (deposition date: 2023-05-26, release date: 2023-09-06, Last modification date: 2023-09-27)
Primary citation	Zhao, C.,Wang, H.,Liu, Y.,Cheng, L.,Wang, B.,Tian, X.,Fu, H.,Wu, C.,Li, Z.,Shen, C.,Yu, J.,Yang, S.,Hu, H.,Fu, P.,Ma, L.,Wang, C.,Yan, W.,Shao, Z. Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol.Cell, 83:3171-, 2023 Cited by PubMed: 37597514 DOI: 10.1016/j.molcel.2023.07.030 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation