8WCA

Cryo-EM structure of the PEA-bound hTAAR1-Gs complex

Summary for 8WCA

Entry DOI	10.2210/pdb8wca/pdb
EMDB information	37436
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Trace amine-associated receptor 1, ... (6 entities in total)
Functional Keywords	pea, htaar1, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	157403.18
Authors	Rong, N.K.,Guo, L.L.,Zhang, M.H.,Li, Q.,Yang, F.,Sun, J.P. (deposition date: 2023-09-11, release date: 2023-12-27)
Primary citation	Shang, P.,Rong, N.,Jiang, J.J.,Cheng, J.,Zhang, M.H.,Kang, D.,Qi, L.,Guo, L.,Yang, G.M.,Liu, Q.,Zhou, Z.,Li, X.B.,Zhu, K.K.,Meng, Q.B.,Han, X.,Yan, W.,Kong, Y.,Yang, L.,Wang, X.,Lei, D.,Feng, X.,Liu, X.,Yu, X.,Wang, Y.,Li, Q.,Shao, Z.H.,Yang, F.,Sun, J.P. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186:5347-5362.e24, 2023 Cited by PubMed: 37963465 DOI: 10.1016/j.cell.2023.10.014 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.48 Å)

Structure validation