7EXD

Lasmiditan-bound serotonin 1F (5-HT1F) receptor-Gi protein complex

Summary for 7EXD

• Entry DOI: 10.2210/pdb7exd/pdb
• EMDB information: 31371
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, serotonin, gi, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 170654.99

Authors

Huang, S.,Xu, P.,Jiang, Y.,Xu, H.E. (deposition date: 2021-05-27, release date: 2021-08-04, Last modification date: 2021-10-06)

• Primary citation: Huang, S.,Xu, P.,Tan, Y.,You, C.,Zhang, Y.,Jiang, Y.,Xu, H.E.; Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT 1F -G protein complex.; Cell Res., 31:1036-1038, 2021; PubMed: 34239069; DOI: 10.1038/s41422-021-00527-4

Experimental method

ELECTRON MICROSCOPY (3.4 Å)