8ZMF
| Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C | 分子名称: | 1-[(4-fluorophenyl)methyl]-1-[(8~{S})-5-methyl-5-azaspiro[2.5]octan-8-yl]-3-[[4-(2-methylpropoxy)phenyl]methyl]urea, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 | 著者 | Oguma, T, Asada, H, Sekiguchi, Y, Imono, M, Iwata, S, Kusakabe, K. | 登録日 | 2024-05-23 | 公開日 | 2024-08-28 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis. J.Med.Chem., 67, 2024
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8DEP
| Cryo-EM structure of the human reduced folate carrier, apo condition | 分子名称: | Digitonin, Reduced folate transporter,Soluble cytochrome b562 | 著者 | Wright, N.J, Fedor, J.G, Lee, S.-Y. | 登録日 | 2022-06-21 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature, 609, 2022
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5NDZ
| Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in complex with AZ3451 at 3.6 angstrom resolution | 分子名称: | 2-(6-bromanyl-1,3-benzodioxol-5-yl)-~{N}-(4-cyanophenyl)-1-[(1~{S})-1-cyclohexylethyl]benzimidazole-5-carboxamide, Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, SODIUM ION | 著者 | Cheng, R.K.Y, Fiez-Vandal, C, Schlenker, O, Edman, K, Aggeler, B, Brown, D.G, Brown, G, Cooke, R.M, Dumelin, C.E, Dore, A.S, Geschwindner, S, Grebner, C, Hermansson, N.-O, Jazayeri, A, Johansson, P, Leong, L, Prihandoko, R, Rappas, M, Soutter, H, Snijder, A, Sundstrom, L, Tehan, B, Thornton, P, Troast, D, Wiggin, G, Zhukov, A, Marshall, F.H, Dekker, N. | 登録日 | 2017-03-09 | 公開日 | 2017-05-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural insight into allosteric modulation of protease-activated receptor 2. Nature, 545, 2017
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7KOQ
| Alpha-7 nicotinic acetylcholine receptor bound to epibatidine in a desensitized state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Cabuco, R, Baxter, L, Borek, D, Sine, S. | 登録日 | 2020-11-09 | 公開日 | 2021-03-17 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor. Cell, 184, 2021
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8HNN
| Structure of CXCR3 complexed with antagonist SCH546738 | 分子名称: | 3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide, CHOLESTEROL, Nb6, ... | 著者 | Jiao, H.Z, Hu, H.L. | 登録日 | 2022-12-08 | 公開日 | 2023-11-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
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8WRZ
| Cry-EM structure of cannabinoid receptor-arrestin 2 complex | 分子名称: | (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Beta-arrestin-1, Soluble cytochrome b562,Cannabinoid receptor 1, ... | 著者 | Wang, Y.X, Wang, T, Wu, L.J, Hua, T, Liu, Z.J. | 登録日 | 2023-10-16 | 公開日 | 2024-02-28 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of cannabinoid receptor CB1-beta-arrestin complex. Protein Cell, 15, 2024
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8W77
| Human Consensus Olfactory Receptor OR52c in apo state, OR52c only | 分子名称: | Human Consensus Olfactory Receptor OR52c in apo state, receptor only,Soluble cytochrome b562 | 著者 | Choi, C.W, Bae, J, Choi, H.-J, Kim, J. | 登録日 | 2023-08-30 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nat Commun, 14, 2023
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8J46
| Human Consensus Olfactory Receptor OR52c in apo state, OR52c-bRIL | 分子名称: | Olfactory receptor OR52c,Soluble cytochrome b562 | 著者 | Choi, C.W, Bae, J, Choi, H.-J, Kim, J. | 登録日 | 2023-04-19 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nat Commun, 14, 2023
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6WW2
| Structure of human Frizzled5 by fiducial-assisted cryo-EM | 分子名称: | Frizzled-5,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, anti-BRIL Fab Light chain, ... | 著者 | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | 登録日 | 2020-05-07 | 公開日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife, 9, 2020
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7SQ0
| Get3 bound to ADP and the transmembrane domain of the tail-anchored protein Bos1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATPase ASNA1 homolog, MAGNESIUM ION, ... | 著者 | Fry, M.Y, Maggiolo, A.O, Clemons Jr, W.M. | 登録日 | 2021-11-04 | 公開日 | 2022-07-20 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3. Nat.Struct.Mol.Biol., 29, 2022
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8XV5
| Pyridoxamine-bound human SLC19A3 | 分子名称: | 4-(AMINOMETHYL)-5-(HYDROXYMETHYL)-2-METHYLPYRIDIN-3-OL, Soluble cytochrome b562,Thiamine transporter 2 | 著者 | Dang, Y, Wang, G.P, Zhang, Z. | 登録日 | 2024-01-14 | 公開日 | 2024-03-27 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Substrate and drug recognition mechanisms of SLC19A3. Cell Res., 34, 2024
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8XV2
| Thiamine-bound human SLC19A3 | 分子名称: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Soluble cytochrome b562,Thiamine transporter 2 | 著者 | Dang, Y, Wang, G.P, Zhang, Z. | 登録日 | 2024-01-14 | 公開日 | 2024-03-27 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Substrate and drug recognition mechanisms of SLC19A3. Cell Res., 34, 2024
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7W0M
| Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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6UR8
| CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ... | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | 登録日 | 2019-10-22 | 公開日 | 2020-04-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
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7WJ5
| Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity | 分子名称: | Gai1 antibody (scfv16), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Heo, Y.S, Yoon, E.J, Jeon, Y.E, Yun, J.-H, Ishimoto, N, Woo, H, Park, S.Y, Song, J, Lee, W.T. | 登録日 | 2022-01-05 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity. Elife, 11, 2022
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8HIK
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6D32
| Crystal structure of Xenopus Smoothened in complex with cyclopamine | 分子名称: | Cyclopamine, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.751 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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7W0O
| Cryo-EM structure of a monomeric GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7TX7
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8XV9
| Fedratinib-bound human SLC19A3 | 分子名称: | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, Soluble cytochrome b562,Thiamine transporter 2 | 著者 | Dang, Y, Wang, G.P, Zhang, Z. | 登録日 | 2024-01-14 | 公開日 | 2024-03-27 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Substrate and drug recognition mechanisms of SLC19A3. Cell Res., 34, 2024
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7EZC
| Adenosine A2a receptor mutant-I92N | 分子名称: | 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,Soluble cytochrome b562 | 著者 | Cui, M, Zhou, Q, Yao, D, Zhao, S, Song, G. | 登録日 | 2021-06-01 | 公開日 | 2022-04-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structure of a constitutive active mutant of adenosine A 2A receptor. Iucrj, 9, 2022
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6USF
| CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | 登録日 | 2019-10-26 | 公開日 | 2020-04-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
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7BW0
| Active human TGR5 complex with a synthetic agonist 23H | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. | 登録日 | 2020-04-12 | 公開日 | 2020-09-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5, 2020
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6D35
| Crystal structure of Xenopus Smoothened in complex with cholesterol | 分子名称: | CHOLESTEROL, Smoothened,Soluble cytochrome b562,Smoothened | 著者 | Huang, P, Zheng, S, Kim, Y, Kruse, A.C, Salic, A. | 登録日 | 2018-04-14 | 公開日 | 2018-05-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174, 2018
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8F7C
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