6D32
Crystal structure of Xenopus Smoothened in complex with cyclopamine
Summary for 6D32
Entry DOI | 10.2210/pdb6d32/pdb |
Descriptor | Smoothened,Soluble cytochrome b562,Smoothened, Cyclopamine (2 entities in total) |
Functional Keywords | gpcr, hedgehog signaling, class frizzled, sterol, membrane protein |
Biological source | Xenopus laevis (African clawed frog) More |
Total number of polymer chains | 1 |
Total formula weight | 69807.54 |
Authors | Huang, P.,Zheng, S.,Kim, Y.,Kruse, A.C.,Salic, A. (deposition date: 2018-04-14, release date: 2018-05-23, Last modification date: 2023-10-04) |
Primary citation | Huang, P.,Zheng, S.,Wierbowski, B.M.,Kim, Y.,Nedelcu, D.,Aravena, L.,Liu, J.,Kruse, A.C.,Salic, A. Structural Basis of Smoothened Activation in Hedgehog Signaling. Cell, 174:312-324.e16, 2018 Cited by PubMed: 29804838DOI: 10.1016/j.cell.2018.04.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.751 Å) |
Structure validation
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