6WW2

Structure of human Frizzled5 by fiducial-assisted cryo-EM

Summary for 6WW2

• Entry DOI: 10.2210/pdb6ww2/pdb
• EMDB information: 21927
• Descriptor: anti-BRIL Fab Heavy chain, anti-Fab Nanobody, anti-BRIL Fab Light chain, ... (4 entities in total)
• Functional Keywords: wnt pathway, frizzled, developmental biology, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 135819.85

Authors

Tsutsumi, N.,Jude, K.M.,Gati, C.,Garcia, K.C. (deposition date: 2020-05-07, release date: 2020-08-19)

• Primary citation: Tsutsumi, N.,Mukherjee, S.,Waghray, D.,Janda, C.Y.,Jude, K.M.,Miao, Y.,Burg, J.S.,Aduri, N.G.,Kossiakoff, A.A.,Gati, C.,Garcia, K.C.; Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.; Elife, 9:-, 2020; PubMed: 32762848; DOI: 10.7554/eLife.58464

Experimental method

ELECTRON MICROSCOPY (3.7 Å)