8HNN

Structure of CXCR3 complexed with antagonist SCH546738

Summary for 8HNN

• Entry DOI: 10.2210/pdb8hnn/pdb
• EMDB information: 34917
• Descriptor: Nb6, Soluble cytochrome b562,C-X-C chemokine receptor type 3,Kappa-type opioid receptor, 3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: g protein coupled receptor, chemokine receptor, cxcr3, sch546738, complex, signaling protein
• Biological source: Lama glama; More
• Total number of polymer chains: 2
• Total formula weight: 75872.06

Authors

Jiao, H.Z.,Hu, H.L. (deposition date: 2022-12-08, release date: 2023-11-29, Last modification date: 2024-01-17)

• Primary citation: Jiao, H.,Pang, B.,Liu, A.,Chen, Q.,Pan, Q.,Wang, X.,Xu, Y.,Chiang, Y.C.,Ren, R.,Hu, H.; Structural insights into the activation and inhibition of CXC chemokine receptor 3.; Nat.Struct.Mol.Biol., 2024; PubMed: 38177682; DOI: 10.1038/s41594-023-01175-5

Experimental method

ELECTRON MICROSCOPY (3.6 Å)