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8HNN

Structure of CXCR3 complexed with antagonist SCH546738

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1NNb6polymer16918665.91Lama glama
2RSoluble cytochrome b562,C-X-C chemokine receptor type 3,Kappa-type opioid receptorpolymer50756327.11UniProt (P0ABE7)
UniProt (P49682)
UniProt (P41145)
In PDB
Escherichia coliCytochrome b-562,CXC-R3,CXCR-3,CKR-L2,G protein-coupled receptor 9,Interferon-inducible protein 10 receptor,IP-10 receptor,K-OR-1,KOR-1
3R3-azanyl-6-chloranyl-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethyl-piperazin-1-yl]pyrazine-2-carboxamidenon-polymer492.41Chemie (43I)
4RCHOLESTEROLnon-polymer386.71Chemie (CLR)
Sequence modifications
R: -111 - -7 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Met -137-initiating methionine
Lys -136-expression tag
Thr -135-expression tag
Ile -134-expression tag
Ile -133-expression tag
Ala -132-expression tag
Leu -131-expression tag
Ser -130-expression tag
Tyr -129-expression tag
Ile -128-expression tag
Phe -127-expression tag
Cys -126-expression tag
Leu -125-expression tag
Val -124-expression tag
Phe -123-expression tag
Ala -122-expression tag
Asp -121-expression tag
Tyr -120-expression tag
Lys -119-expression tag
Asp -118-expression tag
Asp -117-expression tag
Asp -116-expression tag
Asp -115-expression tag
Lys -114-expression tag
Gly -113-expression tag
Ser -112-expression tag
Trp -105Met 29conflict
Ile -10His 124conflict
Leu -6-linker
Leu -5-linker
Val -4-linker
Pro -3-linker
Arg -2-linker
Gly -1-linker
Ser 0-linker
R: 1 - 240 (UniProt: P49682)
R: 241 - 262 (UniProt: P41145)
R: 263 - 369 (UniProt: P49682)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight74993.0
Non-Polymers*Number of molecules2
Total formula weight879.1
All*Total formula weight75872.1
*Water molecules are not included.

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PDB entries from 2024-10-16

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