7W0M

Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule

Summary for 7W0M

Entry DOI	10.2210/pdb7w0m/pdb
EMDB information	32244
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	complex, gpcr, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	172546.02
Authors	Xu, F.,Yue, Y.,Liu, L.E.,Wu, L.J.,Hanson, M. (deposition date: 2021-11-18, release date: 2022-07-27)
Primary citation	Yue, Y.,Liu, L.,Wu, L.J.,Wu, Y.,Wang, L.,Li, F.,Liu, J.,Han, G.W.,Chen, B.,Lin, X.,Brouillette, R.L.,Breault, E.,Longpre, J.M.,Shi, S.,Lei, H.,Sarret, P.,Stevens, R.C.,Hanson, M.A.,Xu, F. Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29:688-697, 2022 Cited by PubMed: 35817871 DOI: 10.1038/s41594-022-00797-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.71 Å)

Structure validation