8ZMF

Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C

This is a non-PDB format compatible entry.

Summary for 8ZMF

• Entry DOI: 10.2210/pdb8zmf/pdb
• Descriptor: 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 1-[(4-fluorophenyl)methyl]-1-[(8~{S})-5-methyl-5-azaspiro[2.5]octan-8-yl]-3-[[4-(2-methylpropoxy)phenyl]methyl]urea (2 entities in total)
• Functional Keywords: class a g protein-coupled receptor, inverse agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 50223.93

Authors

Oguma, T.,Asada, H.,Sekiguchi, Y.,Imono, M.,Iwata, S.,Kusakabe, K. (deposition date: 2024-05-23, release date: 2024-08-28)

• Primary citation: Oguma, T.,Jino, K.,Nakahara, K.,Asada, H.,Fuchino, K.,Nagatani, K.,Kouki, K.,Okamoto, R.,Takai, N.,Koda, K.,Fujita, S.,Sekiguchi, Y.,Yasuo, K.,Mayumi, K.,Abe, A.,Imono, M.,Horiguchi, N.,Iwata, S.,Kusakabe, K.I.; Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis.; J.Med.Chem., 2024; PubMed: 39137033; DOI: 10.1021/acs.jmedchem.4c01244

Experimental method

X-RAY DIFFRACTION (3.6 Å)