8ZMF
Crystal structure of an inverse agonist antipsychotic drug derivative-bound 5-HT2C
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004993 | molecular_function | G protein-coupled serotonin receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImHLCAISLDRYVaI |
| Chain | Residue | Details |
| A | ALA140-ILE156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | PRO56-MET80 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | GLU81-ASN86 | |
| A | ARG152-SER167 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | ALA87-LEU111 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 49 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | LEU112-PRO128 | |
| A | PRO190-ASN213 | |
| A | CYS337-GLU347 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | VAL129-ASP151 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | ARG168-ILE189 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | PHE214-LEU236 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | VAL312-LEU336 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | LYS348-LEU370 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29398112, ECO:0000312|PDB:6BQG |
| Chain | Residue | Details |
| A | THR139 | |
| A | LEU209 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN204 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP1007 | |
| A | ILE1102 |
