7BW0

Active human TGR5 complex with a synthetic agonist 23H

Summary for 7BW0

Entry DOI	10.2210/pdb7bw0/pdb
EMDB information	30221
Descriptor	Soluble cytochrome b562,G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
Functional Keywords	bile acid, gpcr, active complex, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	5
Total formula weight	153772.00
Authors	Chen, G.,Wang, X.K.,Chen, Q.,Hu, H.L.,Ren, R.B. (deposition date: 2020-04-12, release date: 2020-09-02, Last modification date: 2024-03-27)
Primary citation	Chen, G.,Wang, X.,Ge, Y.,Ma, L.,Chen, Q.,Liu, H.,Du, Y.,Ye, R.D.,Hu, H.,Ren, R. Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5:142-142, 2020 Cited by PubMed: 32747649 DOI: 10.1038/s41392-020-00262-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation