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6V94	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 1-[(4-fluorophenyl)methyl]-2-methyl-4-nitro-1H-imidazole, FORMIC ACID, GLYCEROL, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V9J	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 3-(2-aminoethyl)-4-(3-chloro-4-fluorophenoxy)benzene-1-sulfonamide, FORMIC ACID, GLYCEROL, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V65	Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex Descriptor: FORMIC ACID, GTPase KRas, MAGNESIUM ION, ... Authors: Yan, W, Simanshu, D.K. Deposit date: 2019-12-04 Release date: 2020-07-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.763 Å) Cite: Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep, 32, 2020
5DHF	Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.285 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIS	Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat containing fragment of Nup214 Descriptor: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Monecke, T, Port, S.A, Dickmanns, A, Kehlenbach, R.H, Ficner, R. Deposit date: 2015-09-01 Release date: 2015-11-04 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Rep, 13, 2015
6V9M	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 4-fluoro-2-methyl-N-propylbenzene-1-sulfonamide, FORMIC ACID, GLYCEROL, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.648 Å) Cite: Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
5DH9	Crystal Structure of PKI NES Flip Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (PKINES-Flip3 mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
6UZK	Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6 Descriptor: 2-hydroxy-6-methoxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ... Authors: Gingras, A.R. Deposit date: 2019-11-15 Release date: 2020-11-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.924 Å) Cite: Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. Faseb Bioadv, 3, 2021
6V9F	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 1-[(4-chlorophenyl)methyl]-1H-benzimidazol-2-amine, FORMIC ACID, GLYCEROL, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.849 Å) Cite: Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
6V9O	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 3-(phenylsulfonyl)benzene-1-sulfonamide, FORMIC ACID, GLYCEROL, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-12-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.799 Å) Cite: Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods To Be Published
6V9L	Expanding the Chemical Landscape of SOS1 Activators Using Fragment Based Methods Descriptor: 4-(3-chloro-4-fluorophenoxy)benzene-1-sulfonamide, ACETATE ION, FORMIC ACID, ... Authors: Phan, J, Fesik, S.W. Deposit date: 2019-12-13 Release date: 2020-08-26 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.698 Å) Cite: Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods. J.Med.Chem., 63, 2020
5DHA	Crystal Structure of CPEB4 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Engineered Nuclear Export Signal Peptide (CPEB4 NES reverse mutant), Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
5DIF	Crystal Structure of CPEB4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Cytoplasmic polyadenylation element-binding protein 4, Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.092 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
8F7A	Cryo-EM structure of Importin-9 bound to RanGTP Descriptor: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ... Authors: Bernardes, N.E, Chook, Y.M. Deposit date: 2022-11-18 Release date: 2023-07-26 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.78 Å) Cite: Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc.Natl.Acad.Sci.USA, 120, 2023
6W4F	NMR-driven structure of KRAS4B-GDP homodimer on a lipid bilayer nanodisc Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Apolipoprotein A-I, GTPase KRas, ... Authors: Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M. Deposit date: 2020-03-10 Release date: 2020-04-29 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Angew.Chem.Int.Ed.Engl., 59, 2020
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
6TKZ	Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42 Descriptor: Cell division control protein 42 homolog, Dedicator of cytokinesis protein 10, GLYCEROL, ... Authors: Barford, D. Deposit date: 2019-11-29 Release date: 2020-01-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10 Biorxiv, 2022
6TGC	CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. Descriptor: Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 Authors: Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. Deposit date: 2019-11-15 Release date: 2020-07-29 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun, 11, 2020
8HQ6	KL2 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
8HQ3	KL1 in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Jian, L. Deposit date: 2022-12-13 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
6VJJ	Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Tran, T.H, Dharmaiah, S, Simanshu, D.K. Deposit date: 2020-01-16 Release date: 2020-11-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.4 Å) Cite: KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6W4E	NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, ... Authors: Lee, K, Fang, Z, Enomoto, M, Gasmi-Seabrook, G.M, Zheng, L, Marshall, C.B, Ikura, M. Deposit date: 2020-03-10 Release date: 2020-04-15 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Angew.Chem.Int.Ed.Engl., 59, 2020
8HQ4	B27 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... Authors: Lei, Y, Sun, Q. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.12 Å) Cite: B27 in complex with CRM1-Ran-RanBP1 To Be Published
8HQ5	G6 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.25 Å) Cite: F1 in complex with CRM1-Ran-RanBP1 To Be Published
5DLQ	Crystal structure of RanGTP-Exportin 4-eIF5A complex Descriptor: Eukaryotic translation initiation factor 5A-1, Exportin-4, GTP-binding nuclear protein Ran, ... Authors: Aksu, M, Trakhanov, S, Gorlich, D. Deposit date: 2015-09-07 Release date: 2016-06-22 Last modified: 2016-06-29 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun, 7, 2016

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