6TGC

CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex.

This is a non-PDB format compatible entry.

Summary for 6TGC

• Entry DOI: 10.2210/pdb6tgc/pdb
• EMDB information: 10498
• Descriptor: Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 (3 entities in total)
• Functional Keywords: guanine nucleotide exchange factor, cytoskeleton, actin, cryoem, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 602543.91

Authors

Chang, L.,Yang, J.,Chang, J.H.,Zhang, Z.,Boland, A.,McLaughlin, S.H.,Abu-Thuraia, A.,Killoran, R.C.,Smith, M.J.,Cote, J.F.,Barford, D. (deposition date: 2019-11-15, release date: 2020-07-29, Last modification date: 2023-07-26)

• Primary citation: Chang, L.,Yang, J.,Jo, C.H.,Boland, A.,Zhang, Z.,McLaughlin, S.H.,Abu-Thuraia, A.,Killoran, R.C.,Smith, M.J.,Cote, J.F.,Barford, D.; Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.; Nat Commun, 11:3464-3464, 2020; PubMed: 32651375; DOI: 10.1038/s41467-020-17271-9

Experimental method

ELECTRON MICROSCOPY (4.1 Å)