6TGC

CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001766	biological_process	membrane raft polarization
A	0001768	biological_process	establishment of T cell polarity
A	0001771	biological_process	immunological synapse formation
A	0002277	biological_process	myeloid dendritic cell activation involved in immune response
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005096	molecular_function	GTPase activator activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006935	biological_process	chemotaxis
A	0007010	biological_process	cytoskeleton organization
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0007520	biological_process	myoblast fusion
A	0012505	cellular_component	endomembrane system
A	0016020	cellular_component	membrane
A	0016477	biological_process	cell migration
A	0030036	biological_process	actin cytoskeleton organization
A	0031267	molecular_function	small GTPase binding
A	0035580	cellular_component	specific granule lumen
A	0042098	biological_process	T cell proliferation
A	0042110	biological_process	T cell activation
A	0042608	molecular_function	T cell receptor binding
A	0044351	biological_process	macropinocytosis
A	0045059	biological_process	positive thymic T cell selection
A	0045060	biological_process	negative thymic T cell selection
A	0046631	biological_process	alpha-beta T cell activation
A	0046633	biological_process	alpha-beta T cell proliferation
A	0050766	biological_process	positive regulation of phagocytosis
A	0051056	biological_process	regulation of small GTPase mediated signal transduction
A	0070062	cellular_component	extracellular exosome
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006909	biological_process	phagocytosis
B	0006911	biological_process	phagocytosis, engulfment
B	0006915	biological_process	apoptotic process
B	0007015	biological_process	actin filament organization
B	0016020	cellular_component	membrane
B	0016601	biological_process	Rac protein signal transduction
B	0017124	molecular_function	SH3 domain binding
B	0030029	biological_process	actin filament-based process
B	0030036	biological_process	actin cytoskeleton organization
B	0032045	cellular_component	guanyl-nucleotide exchange factor complex
B	0048870	biological_process	cell motility
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0150052	biological_process	regulation of postsynapse assembly
C	0000166	molecular_function	nucleotide binding
C	0000242	cellular_component	pericentriolar material
C	0001764	biological_process	neuron migration
C	0001891	cellular_component	phagocytic cup
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0002093	biological_process	auditory receptor cell morphogenesis
C	0003015	biological_process	heart process
C	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
C	0003382	biological_process	epithelial cell morphogenesis
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005802	cellular_component	trans-Golgi network
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005884	cellular_component	actin filament
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0005938	cellular_component	cell cortex
C	0006897	biological_process	endocytosis
C	0006911	biological_process	phagocytosis, engulfment
C	0006954	biological_process	inflammatory response
C	0006972	biological_process	hyperosmotic response
C	0007010	biological_process	cytoskeleton organization
C	0007015	biological_process	actin filament organization
C	0007155	biological_process	cell adhesion
C	0007160	biological_process	cell-matrix adhesion
C	0007163	biological_process	establishment or maintenance of cell polarity
C	0007167	biological_process	enzyme-linked receptor protein signaling pathway
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0007411	biological_process	axon guidance
C	0008045	biological_process	motor neuron axon guidance
C	0008360	biological_process	regulation of cell shape
C	0009611	biological_process	response to wounding
C	0009653	biological_process	anatomical structure morphogenesis
C	0010310	biological_process	regulation of hydrogen peroxide metabolic process
C	0010591	biological_process	regulation of lamellipodium assembly
C	0010592	biological_process	positive regulation of lamellipodium assembly
C	0010595	biological_process	positive regulation of endothelial cell migration
C	0010762	biological_process	regulation of fibroblast migration
C	0010764	biological_process	negative regulation of fibroblast migration
C	0010810	biological_process	regulation of cell-substrate adhesion
C	0014041	biological_process	regulation of neuron maturation
C	0016020	cellular_component	membrane
C	0016358	biological_process	dendrite development
C	0016477	biological_process	cell migration
C	0016601	biological_process	Rac protein signal transduction
C	0016787	molecular_function	hydrolase activity
C	0019805	biological_process	quinolinate biosynthetic process
C	0019899	molecular_function	enzyme binding
C	0019901	molecular_function	protein kinase binding
C	0021799	biological_process	cerebral cortex radially oriented cell migration
C	0021831	biological_process	embryonic olfactory bulb interneuron precursor migration
C	0021894	biological_process	cerebral cortex GABAergic interneuron development
C	0022604	biological_process	regulation of cell morphogenesis
C	0030027	cellular_component	lamellipodium
C	0030031	biological_process	cell projection assembly
C	0030032	biological_process	lamellipodium assembly
C	0030036	biological_process	actin cytoskeleton organization
C	0030041	biological_process	actin filament polymerization
C	0030334	biological_process	regulation of cell migration
C	0030425	cellular_component	dendrite
C	0030667	cellular_component	secretory granule membrane
C	0030672	cellular_component	synaptic vesicle membrane
C	0030742	molecular_function	GTP-dependent protein binding
C	0030838	biological_process	positive regulation of actin filament polymerization
C	0030865	biological_process	cortical cytoskeleton organization
C	0030900	biological_process	forebrain development
C	0031410	cellular_component	cytoplasmic vesicle
C	0031529	biological_process	ruffle organization
C	0031901	cellular_component	early endosome membrane
C	0031996	molecular_function	thioesterase binding
C	0032496	biological_process	response to lipopolysaccharide
C	0032587	cellular_component	ruffle membrane
C	0032707	biological_process	negative regulation of interleukin-23 production
C	0032956	biological_process	regulation of actin cytoskeleton organization
C	0034446	biological_process	substrate adhesion-dependent cell spreading
C	0035025	biological_process	positive regulation of Rho protein signal transduction
C	0035556	biological_process	intracellular signal transduction
C	0035567	biological_process	non-canonical Wnt signaling pathway
C	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042470	cellular_component	melanosome
C	0042554	biological_process	superoxide anion generation
C	0042734	cellular_component	presynaptic membrane
C	0042995	cellular_component	cell projection
C	0043020	cellular_component	NADPH oxidase complex
C	0043131	biological_process	erythrocyte enucleation
C	0043652	biological_process	engulfment of apoptotic cell
C	0044877	molecular_function	protein-containing complex binding
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0045216	biological_process	cell-cell junction organization
C	0045428	biological_process	regulation of nitric oxide biosynthetic process
C	0045730	biological_process	respiratory burst
C	0046425	biological_process	regulation of receptor signaling pathway via JAK-STAT
C	0048012	biological_process	hepatocyte growth factor receptor signaling pathway
C	0048168	biological_process	regulation of neuronal synaptic plasticity
C	0048261	biological_process	negative regulation of receptor-mediated endocytosis
C	0048532	biological_process	anatomical structure arrangement
C	0048812	biological_process	neuron projection morphogenesis
C	0048813	biological_process	dendrite morphogenesis
C	0048870	biological_process	cell motility
C	0048873	biological_process	homeostasis of number of cells within a tissue
C	0051022	molecular_function	Rho GDP-dissociation inhibitor binding
C	0051492	biological_process	regulation of stress fiber assembly
C	0051496	biological_process	positive regulation of stress fiber assembly
C	0051668	biological_process	localization within membrane
C	0051894	biological_process	positive regulation of focal adhesion assembly
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C	0051932	biological_process	synaptic transmission, GABAergic
C	0055038	cellular_component	recycling endosome membrane
C	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
C	0060091	cellular_component	kinocilium
C	0060263	biological_process	regulation of respiratory burst
C	0060326	biological_process	cell chemotaxis
C	0060999	biological_process	positive regulation of dendritic spine development
C	0061344	biological_process	regulation of cell adhesion involved in heart morphogenesis
C	0070062	cellular_component	extracellular exosome
C	0070376	biological_process	regulation of ERK5 cascade
C	0071526	biological_process	semaphorin-plexin signaling pathway
C	0071542	biological_process	dopaminergic neuron differentiation
C	0072659	biological_process	protein localization to plasma membrane
C	0086098	biological_process	angiotensin-activated signaling pathway involved in heart process
C	0090023	biological_process	positive regulation of neutrophil chemotaxis
C	0090103	biological_process	cochlea morphogenesis
C	0097178	biological_process	ruffle assembly
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0101003	cellular_component	ficolin-1-rich granule membrane
C	0150052	biological_process	regulation of postsynapse assembly
C	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
C	1900029	biological_process	positive regulation of ruffle assembly
C	1900242	biological_process	regulation of synaptic vesicle endocytosis
C	1902622	biological_process	regulation of neutrophil migration
C	1903348	biological_process	positive regulation of bicellular tight junction assembly
C	1904395	biological_process	positive regulation of skeletal muscle acetylcholine-gated channel clustering
C	1904936	biological_process	interneuron migration
C	1904948	biological_process	midbrain dopaminergic neuron differentiation
C	2000386	biological_process	positive regulation of ovarian follicle development
C	2001222	biological_process	regulation of neuron migration
D	0001766	biological_process	membrane raft polarization
D	0001768	biological_process	establishment of T cell polarity
D	0001771	biological_process	immunological synapse formation
D	0002277	biological_process	myeloid dendritic cell activation involved in immune response
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005096	molecular_function	GTPase activator activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006935	biological_process	chemotaxis
D	0007010	biological_process	cytoskeleton organization
D	0007264	biological_process	small GTPase-mediated signal transduction
D	0007520	biological_process	myoblast fusion
D	0012505	cellular_component	endomembrane system
D	0016020	cellular_component	membrane
D	0016477	biological_process	cell migration
D	0030036	biological_process	actin cytoskeleton organization
D	0031267	molecular_function	small GTPase binding
D	0035580	cellular_component	specific granule lumen
D	0042098	biological_process	T cell proliferation
D	0042110	biological_process	T cell activation
D	0042608	molecular_function	T cell receptor binding
D	0044351	biological_process	macropinocytosis
D	0045059	biological_process	positive thymic T cell selection
D	0045060	biological_process	negative thymic T cell selection
D	0046631	biological_process	alpha-beta T cell activation
D	0046633	biological_process	alpha-beta T cell proliferation
D	0050766	biological_process	positive regulation of phagocytosis
D	0051056	biological_process	regulation of small GTPase mediated signal transduction
D	0070062	cellular_component	extracellular exosome
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006909	biological_process	phagocytosis
E	0006911	biological_process	phagocytosis, engulfment
E	0006915	biological_process	apoptotic process
E	0007015	biological_process	actin filament organization
E	0016020	cellular_component	membrane
E	0016601	biological_process	Rac protein signal transduction
E	0017124	molecular_function	SH3 domain binding
E	0030029	biological_process	actin filament-based process
E	0030036	biological_process	actin cytoskeleton organization
E	0032045	cellular_component	guanyl-nucleotide exchange factor complex
E	0048870	biological_process	cell motility
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0150052	biological_process	regulation of postsynapse assembly
F	0000166	molecular_function	nucleotide binding
F	0000242	cellular_component	pericentriolar material
F	0001764	biological_process	neuron migration
F	0001891	cellular_component	phagocytic cup
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0002093	biological_process	auditory receptor cell morphogenesis
F	0003015	biological_process	heart process
F	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
F	0003382	biological_process	epithelial cell morphogenesis
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005802	cellular_component	trans-Golgi network
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005884	cellular_component	actin filament
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0005938	cellular_component	cell cortex
F	0006897	biological_process	endocytosis
F	0006911	biological_process	phagocytosis, engulfment
F	0006954	biological_process	inflammatory response
F	0006972	biological_process	hyperosmotic response
F	0007010	biological_process	cytoskeleton organization
F	0007015	biological_process	actin filament organization
F	0007155	biological_process	cell adhesion
F	0007160	biological_process	cell-matrix adhesion
F	0007163	biological_process	establishment or maintenance of cell polarity
F	0007167	biological_process	enzyme-linked receptor protein signaling pathway
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007264	biological_process	small GTPase-mediated signal transduction
F	0007411	biological_process	axon guidance
F	0008045	biological_process	motor neuron axon guidance
F	0008360	biological_process	regulation of cell shape
F	0009611	biological_process	response to wounding
F	0009653	biological_process	anatomical structure morphogenesis
F	0010310	biological_process	regulation of hydrogen peroxide metabolic process
F	0010591	biological_process	regulation of lamellipodium assembly
F	0010592	biological_process	positive regulation of lamellipodium assembly
F	0010595	biological_process	positive regulation of endothelial cell migration
F	0010762	biological_process	regulation of fibroblast migration
F	0010764	biological_process	negative regulation of fibroblast migration
F	0010810	biological_process	regulation of cell-substrate adhesion
F	0014041	biological_process	regulation of neuron maturation
F	0016020	cellular_component	membrane
F	0016358	biological_process	dendrite development
F	0016477	biological_process	cell migration
F	0016601	biological_process	Rac protein signal transduction
F	0016787	molecular_function	hydrolase activity
F	0019805	biological_process	quinolinate biosynthetic process
F	0019899	molecular_function	enzyme binding
F	0019901	molecular_function	protein kinase binding
F	0021799	biological_process	cerebral cortex radially oriented cell migration
F	0021831	biological_process	embryonic olfactory bulb interneuron precursor migration
F	0021894	biological_process	cerebral cortex GABAergic interneuron development
F	0022604	biological_process	regulation of cell morphogenesis
F	0030027	cellular_component	lamellipodium
F	0030031	biological_process	cell projection assembly
F	0030032	biological_process	lamellipodium assembly
F	0030036	biological_process	actin cytoskeleton organization
F	0030041	biological_process	actin filament polymerization
F	0030334	biological_process	regulation of cell migration
F	0030425	cellular_component	dendrite
F	0030667	cellular_component	secretory granule membrane
F	0030672	cellular_component	synaptic vesicle membrane
F	0030742	molecular_function	GTP-dependent protein binding
F	0030838	biological_process	positive regulation of actin filament polymerization
F	0030865	biological_process	cortical cytoskeleton organization
F	0030900	biological_process	forebrain development
F	0031410	cellular_component	cytoplasmic vesicle
F	0031529	biological_process	ruffle organization
F	0031901	cellular_component	early endosome membrane
F	0031996	molecular_function	thioesterase binding
F	0032496	biological_process	response to lipopolysaccharide
F	0032587	cellular_component	ruffle membrane
F	0032707	biological_process	negative regulation of interleukin-23 production
F	0032956	biological_process	regulation of actin cytoskeleton organization
F	0034446	biological_process	substrate adhesion-dependent cell spreading
F	0035025	biological_process	positive regulation of Rho protein signal transduction
F	0035556	biological_process	intracellular signal transduction
F	0035567	biological_process	non-canonical Wnt signaling pathway
F	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
F	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
F	0042470	cellular_component	melanosome
F	0042554	biological_process	superoxide anion generation
F	0042734	cellular_component	presynaptic membrane
F	0042995	cellular_component	cell projection
F	0043020	cellular_component	NADPH oxidase complex
F	0043131	biological_process	erythrocyte enucleation
F	0043652	biological_process	engulfment of apoptotic cell
F	0044877	molecular_function	protein-containing complex binding
F	0045202	cellular_component	synapse
F	0045211	cellular_component	postsynaptic membrane
F	0045216	biological_process	cell-cell junction organization
F	0045428	biological_process	regulation of nitric oxide biosynthetic process
F	0045730	biological_process	respiratory burst
F	0046425	biological_process	regulation of receptor signaling pathway via JAK-STAT
F	0048012	biological_process	hepatocyte growth factor receptor signaling pathway
F	0048168	biological_process	regulation of neuronal synaptic plasticity
F	0048261	biological_process	negative regulation of receptor-mediated endocytosis
F	0048532	biological_process	anatomical structure arrangement
F	0048812	biological_process	neuron projection morphogenesis
F	0048813	biological_process	dendrite morphogenesis
F	0048870	biological_process	cell motility
F	0048873	biological_process	homeostasis of number of cells within a tissue
F	0051022	molecular_function	Rho GDP-dissociation inhibitor binding
F	0051492	biological_process	regulation of stress fiber assembly
F	0051496	biological_process	positive regulation of stress fiber assembly
F	0051668	biological_process	localization within membrane
F	0051894	biological_process	positive regulation of focal adhesion assembly
F	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0051932	biological_process	synaptic transmission, GABAergic
F	0055038	cellular_component	recycling endosome membrane
F	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
F	0060091	cellular_component	kinocilium
F	0060263	biological_process	regulation of respiratory burst
F	0060326	biological_process	cell chemotaxis
F	0060999	biological_process	positive regulation of dendritic spine development
F	0061344	biological_process	regulation of cell adhesion involved in heart morphogenesis
F	0070062	cellular_component	extracellular exosome
F	0070376	biological_process	regulation of ERK5 cascade
F	0071526	biological_process	semaphorin-plexin signaling pathway
F	0071542	biological_process	dopaminergic neuron differentiation
F	0072659	biological_process	protein localization to plasma membrane
F	0086098	biological_process	angiotensin-activated signaling pathway involved in heart process
F	0090023	biological_process	positive regulation of neutrophil chemotaxis
F	0090103	biological_process	cochlea morphogenesis
F	0097178	biological_process	ruffle assembly
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0101003	cellular_component	ficolin-1-rich granule membrane
F	0150052	biological_process	regulation of postsynapse assembly
F	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
F	1900029	biological_process	positive regulation of ruffle assembly
F	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	1902622	biological_process	regulation of neutrophil migration
F	1903348	biological_process	positive regulation of bicellular tight junction assembly
F	1904395	biological_process	positive regulation of skeletal muscle acetylcholine-gated channel clustering
F	1904936	biological_process	interneuron migration
F	1904948	biological_process	midbrain dopaminergic neuron differentiation
F	2000386	biological_process	positive regulation of ovarian follicle development
F	2001222	biological_process	regulation of neuron migration

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Motif: {"description":"SH3-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine; by HCK","evidences":[{"source":"PubMed","id":"15952790","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18093184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23512198","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---