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6TGC

CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex.

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001766biological_processmembrane raft polarization
A0001768biological_processestablishment of T cell polarity
A0001771biological_processimmunological synapse formation
A0002277biological_processmyeloid dendritic cell activation involved in immune response
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006935biological_processchemotaxis
A0007010biological_processcytoskeleton organization
A0007264biological_processsmall GTPase-mediated signal transduction
A0007520biological_processmyoblast fusion
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0030036biological_processactin cytoskeleton organization
A0031267molecular_functionsmall GTPase binding
A0035580cellular_componentspecific granule lumen
A0042098biological_processT cell proliferation
A0042110biological_processT cell activation
A0042608molecular_functionT cell receptor binding
A0044351biological_processmacropinocytosis
A0045059biological_processpositive thymic T cell selection
A0045060biological_processnegative thymic T cell selection
A0046631biological_processalpha-beta T cell activation
A0046633biological_processalpha-beta T cell proliferation
A0050766biological_processpositive regulation of phagocytosis
A0051056biological_processregulation of small GTPase mediated signal transduction
A0070062cellular_componentextracellular exosome
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006909biological_processphagocytosis
B0006911biological_processphagocytosis, engulfment
B0006915biological_processapoptotic process
B0007015biological_processactin filament organization
B0016020cellular_componentmembrane
B0016601biological_processRac protein signal transduction
B0017124molecular_functionSH3 domain binding
B0030029biological_processactin filament-based process
B0030036biological_processactin cytoskeleton organization
B0032045cellular_componentguanyl-nucleotide exchange factor complex
B0048870biological_processcell motility
C0000166molecular_functionnucleotide binding
C0001764biological_processneuron migration
C0001934biological_processpositive regulation of protein phosphorylation
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006954biological_processinflammatory response
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007264biological_processsmall GTPase-mediated signal transduction
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0008361biological_processregulation of cell size
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010764biological_processnegative regulation of fibroblast migration
C0010811biological_processpositive regulation of cell-substrate adhesion
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030865biological_processcortical cytoskeleton organization
C0031116biological_processpositive regulation of microtubule polymerization
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031996molecular_functionthioesterase binding
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043197cellular_componentdendritic spine
C0043652biological_processengulfment of apoptotic cell
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048870biological_processcell motility
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051179biological_processlocalization
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0070062cellular_componentextracellular exosome
C0071526biological_processsemaphorin-plexin signaling pathway
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1902622biological_processregulation of neutrophil migration
D0001766biological_processmembrane raft polarization
D0001768biological_processestablishment of T cell polarity
D0001771biological_processimmunological synapse formation
D0002277biological_processmyeloid dendritic cell activation involved in immune response
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005096molecular_functionGTPase activator activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006935biological_processchemotaxis
D0007010biological_processcytoskeleton organization
D0007264biological_processsmall GTPase-mediated signal transduction
D0007520biological_processmyoblast fusion
D0012505cellular_componentendomembrane system
D0016020cellular_componentmembrane
D0016477biological_processcell migration
D0030036biological_processactin cytoskeleton organization
D0031267molecular_functionsmall GTPase binding
D0035580cellular_componentspecific granule lumen
D0042098biological_processT cell proliferation
D0042110biological_processT cell activation
D0042608molecular_functionT cell receptor binding
D0044351biological_processmacropinocytosis
D0045059biological_processpositive thymic T cell selection
D0045060biological_processnegative thymic T cell selection
D0046631biological_processalpha-beta T cell activation
D0046633biological_processalpha-beta T cell proliferation
D0050766biological_processpositive regulation of phagocytosis
D0051056biological_processregulation of small GTPase mediated signal transduction
D0070062cellular_componentextracellular exosome
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006909biological_processphagocytosis
E0006911biological_processphagocytosis, engulfment
E0006915biological_processapoptotic process
E0007015biological_processactin filament organization
E0016020cellular_componentmembrane
E0016601biological_processRac protein signal transduction
E0017124molecular_functionSH3 domain binding
E0030029biological_processactin filament-based process
E0030036biological_processactin cytoskeleton organization
E0032045cellular_componentguanyl-nucleotide exchange factor complex
E0048870biological_processcell motility
F0000166molecular_functionnucleotide binding
F0001764biological_processneuron migration
F0001934biological_processpositive regulation of protein phosphorylation
F0003376biological_processsphingosine-1-phosphate receptor signaling pathway
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005789cellular_componentendoplasmic reticulum membrane
F0005802cellular_componenttrans-Golgi network
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005884cellular_componentactin filament
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0005938cellular_componentcell cortex
F0006954biological_processinflammatory response
F0007015biological_processactin filament organization
F0007155biological_processcell adhesion
F0007160biological_processcell-matrix adhesion
F0007163biological_processestablishment or maintenance of cell polarity
F0007264biological_processsmall GTPase-mediated signal transduction
F0008045biological_processmotor neuron axon guidance
F0008360biological_processregulation of cell shape
F0008361biological_processregulation of cell size
F0009611biological_processresponse to wounding
F0009653biological_processanatomical structure morphogenesis
F0010310biological_processregulation of hydrogen peroxide metabolic process
F0010591biological_processregulation of lamellipodium assembly
F0010592biological_processpositive regulation of lamellipodium assembly
F0010595biological_processpositive regulation of endothelial cell migration
F0010764biological_processnegative regulation of fibroblast migration
F0010811biological_processpositive regulation of cell-substrate adhesion
F0016020cellular_componentmembrane
F0016477biological_processcell migration
F0016601biological_processRac protein signal transduction
F0016787molecular_functionhydrolase activity
F0019899molecular_functionenzyme binding
F0019901molecular_functionprotein kinase binding
F0030027cellular_componentlamellipodium
F0030031biological_processcell projection assembly
F0030032biological_processlamellipodium assembly
F0030036biological_processactin cytoskeleton organization
F0030041biological_processactin filament polymerization
F0030334biological_processregulation of cell migration
F0030425cellular_componentdendrite
F0030667cellular_componentsecretory granule membrane
F0030865biological_processcortical cytoskeleton organization
F0031116biological_processpositive regulation of microtubule polymerization
F0031410cellular_componentcytoplasmic vesicle
F0031529biological_processruffle organization
F0031996molecular_functionthioesterase binding
F0032587cellular_componentruffle membrane
F0032707biological_processnegative regulation of interleukin-23 production
F0032956biological_processregulation of actin cytoskeleton organization
F0034446biological_processsubstrate adhesion-dependent cell spreading
F0035025biological_processpositive regulation of Rho protein signal transduction
F0035556biological_processintracellular signal transduction
F0036464cellular_componentcytoplasmic ribonucleoprotein granule
F0042470cellular_componentmelanosome
F0042995cellular_componentcell projection
F0043020cellular_componentNADPH oxidase complex
F0043197cellular_componentdendritic spine
F0043652biological_processengulfment of apoptotic cell
F0044877molecular_functionprotein-containing complex binding
F0045202cellular_componentsynapse
F0045428biological_processregulation of nitric oxide biosynthetic process
F0045730biological_processrespiratory burst
F0048012biological_processhepatocyte growth factor receptor signaling pathway
F0048261biological_processnegative regulation of receptor-mediated endocytosis
F0048870biological_processcell motility
F0051022molecular_functionRho GDP-dissociation inhibitor binding
F0051179biological_processlocalization
F0051492biological_processregulation of stress fiber assembly
F0051496biological_processpositive regulation of stress fiber assembly
F0051668biological_processlocalization within membrane
F0051894biological_processpositive regulation of focal adhesion assembly
F0055038cellular_componentrecycling endosome membrane
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0060263biological_processregulation of respiratory burst
F0060326biological_processcell chemotaxis
F0070062cellular_componentextracellular exosome
F0071526biological_processsemaphorin-plexin signaling pathway
F0090023biological_processpositive regulation of neutrophil chemotaxis
F0097178biological_processruffle assembly
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0101003cellular_componentficolin-1-rich granule membrane
F1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
F1902622biological_processregulation of neutrophil migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
CALA13
ETYR720
CGLY30
CGLY60
FALA13
FGLY30
FGLY60
ETYR216
ETYR395
ETYR511

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
CLYS116
CALA159
FLYS116
FALA159

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
CTYR32
FTYR32

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
CTHR35
FTHR35
DSER1706
DSER1784

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
CSER71
FSER71

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
CCYS189
FCYS189

site_idSWS_FT_FI7
Number of Residues4
DetailsLIPID: (Microbial infection) N6-palmitoyl lysine => ECO:0000269|PubMed:29074776
ChainResidueDetails
CLYS183
CLYS184
FLYS183
FLYS184

site_idSWS_FT_FI8
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:1903399
ChainResidueDetails
CCYS189
FCYS189

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
CTYR32
FTYR32

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
CTHR35
FTHR35

site_idSWS_FT_FI11
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
CLYS147
FLYS147

site_idSWS_FT_FI12
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
CLYS166
FLYS166

218853

PDB entries from 2024-04-24

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