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6TGC

CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex.

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001766biological_processmembrane raft polarization
A0001768biological_processestablishment of T cell polarity
A0001771biological_processimmunological synapse formation
A0002277biological_processmyeloid dendritic cell activation involved in immune response
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006935biological_processchemotaxis
A0007010biological_processcytoskeleton organization
A0007264biological_processsmall GTPase-mediated signal transduction
A0007520biological_processmyoblast fusion
A0012505cellular_componentendomembrane system
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0030036biological_processactin cytoskeleton organization
A0031267molecular_functionsmall GTPase binding
A0035580cellular_componentspecific granule lumen
A0042098biological_processT cell proliferation
A0042110biological_processT cell activation
A0042608molecular_functionT cell receptor binding
A0044351biological_processmacropinocytosis
A0045059biological_processpositive thymic T cell selection
A0045060biological_processnegative thymic T cell selection
A0046631biological_processalpha-beta T cell activation
A0046633biological_processalpha-beta T cell proliferation
A0050766biological_processpositive regulation of phagocytosis
A0051056biological_processregulation of small GTPase mediated signal transduction
A0070062cellular_componentextracellular exosome
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006909biological_processphagocytosis
B0006911biological_processphagocytosis, engulfment
B0006915biological_processapoptotic process
B0007015biological_processactin filament organization
B0016020cellular_componentmembrane
B0016601biological_processRac protein signal transduction
B0017124molecular_functionSH3 domain binding
B0030029biological_processactin filament-based process
B0030036biological_processactin cytoskeleton organization
B0032045cellular_componentguanyl-nucleotide exchange factor complex
B0048870biological_processcell motility
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0150052biological_processregulation of postsynapse assembly
C0000166molecular_functionnucleotide binding
C0000242cellular_componentpericentriolar material
C0001764biological_processneuron migration
C0001891cellular_componentphagocytic cup
C0001934biological_processpositive regulation of protein phosphorylation
C0002093biological_processauditory receptor cell morphogenesis
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003382biological_processepithelial cell morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0006954biological_processinflammatory response
C0006972biological_processhyperosmotic response
C0007010biological_processcytoskeleton organization
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007167biological_processenzyme-linked receptor protein signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007411biological_processaxon guidance
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010762biological_processregulation of fibroblast migration
C0010764biological_processnegative regulation of fibroblast migration
C0010810biological_processregulation of cell-substrate adhesion
C0010811biological_processpositive regulation of cell-substrate adhesion
C0014041biological_processregulation of neuron maturation
C0016020cellular_componentmembrane
C0016358biological_processdendrite development
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0021799biological_processcerebral cortex radially oriented cell migration
C0021831biological_processembryonic olfactory bulb interneuron precursor migration
C0021894biological_processcerebral cortex GABAergic interneuron development
C0022604biological_processregulation of cell morphogenesis
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030672cellular_componentsynaptic vesicle membrane
C0030742molecular_functionGTP-dependent protein binding
C0030838biological_processpositive regulation of actin filament polymerization
C0030865biological_processcortical cytoskeleton organization
C0030900biological_processforebrain development
C0031116biological_processpositive regulation of microtubule polymerization
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031901cellular_componentearly endosome membrane
C0031996molecular_functionthioesterase binding
C0032496biological_processresponse to lipopolysaccharide
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0035567biological_processnon-canonical Wnt signaling pathway
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042554biological_processsuperoxide anion generation
C0042734cellular_componentpresynaptic membrane
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043131biological_processerythrocyte enucleation
C0043652biological_processengulfment of apoptotic cell
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045216biological_processcell-cell junction organization
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0046425biological_processregulation of receptor signaling pathway via JAK-STAT
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048168biological_processregulation of neuronal synaptic plasticity
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048532biological_processanatomical structure arrangement
C0048812biological_processneuron projection morphogenesis
C0048813biological_processdendrite morphogenesis
C0048870biological_processcell motility
C0048873biological_processhomeostasis of number of cells within a tissue
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051932biological_processsynaptic transmission, GABAergic
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060091cellular_componentkinocilium
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0060999biological_processpositive regulation of dendritic spine development
C0061344biological_processregulation of cell adhesion involved in heart morphogenesis
C0070062cellular_componentextracellular exosome
C0070376biological_processregulation of ERK5 cascade
C0071526biological_processsemaphorin-plexin signaling pathway
C0071542biological_processdopaminergic neuron differentiation
C0072659biological_processprotein localization to plasma membrane
C0086098biological_processangiotensin-activated signaling pathway involved in heart process
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0090103biological_processcochlea morphogenesis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C0150052biological_processregulation of postsynapse assembly
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1900029biological_processpositive regulation of ruffle assembly
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902622biological_processregulation of neutrophil migration
C1903348biological_processpositive regulation of bicellular tight junction assembly
C1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
C1904936biological_processinterneuron migration
C1904948biological_processmidbrain dopaminergic neuron differentiation
C2000386biological_processpositive regulation of ovarian follicle development
C2001222biological_processregulation of neuron migration
D0001766biological_processmembrane raft polarization
D0001768biological_processestablishment of T cell polarity
D0001771biological_processimmunological synapse formation
D0002277biological_processmyeloid dendritic cell activation involved in immune response
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005096molecular_functionGTPase activator activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006935biological_processchemotaxis
D0007010biological_processcytoskeleton organization
D0007264biological_processsmall GTPase-mediated signal transduction
D0007520biological_processmyoblast fusion
D0012505cellular_componentendomembrane system
D0016020cellular_componentmembrane
D0016477biological_processcell migration
D0030036biological_processactin cytoskeleton organization
D0031267molecular_functionsmall GTPase binding
D0035580cellular_componentspecific granule lumen
D0042098biological_processT cell proliferation
D0042110biological_processT cell activation
D0042608molecular_functionT cell receptor binding
D0044351biological_processmacropinocytosis
D0045059biological_processpositive thymic T cell selection
D0045060biological_processnegative thymic T cell selection
D0046631biological_processalpha-beta T cell activation
D0046633biological_processalpha-beta T cell proliferation
D0050766biological_processpositive regulation of phagocytosis
D0051056biological_processregulation of small GTPase mediated signal transduction
D0070062cellular_componentextracellular exosome
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006909biological_processphagocytosis
E0006911biological_processphagocytosis, engulfment
E0006915biological_processapoptotic process
E0007015biological_processactin filament organization
E0016020cellular_componentmembrane
E0016601biological_processRac protein signal transduction
E0017124molecular_functionSH3 domain binding
E0030029biological_processactin filament-based process
E0030036biological_processactin cytoskeleton organization
E0032045cellular_componentguanyl-nucleotide exchange factor complex
E0048870biological_processcell motility
E0098794cellular_componentpostsynapse
E0098978cellular_componentglutamatergic synapse
E0150052biological_processregulation of postsynapse assembly
F0000166molecular_functionnucleotide binding
F0000242cellular_componentpericentriolar material
F0001764biological_processneuron migration
F0001891cellular_componentphagocytic cup
F0001934biological_processpositive regulation of protein phosphorylation
F0002093biological_processauditory receptor cell morphogenesis
F0003376biological_processsphingosine-1-phosphate receptor signaling pathway
F0003382biological_processepithelial cell morphogenesis
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005789cellular_componentendoplasmic reticulum membrane
F0005802cellular_componenttrans-Golgi network
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005884cellular_componentactin filament
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0005938cellular_componentcell cortex
F0006897biological_processendocytosis
F0006911biological_processphagocytosis, engulfment
F0006954biological_processinflammatory response
F0006972biological_processhyperosmotic response
F0007010biological_processcytoskeleton organization
F0007015biological_processactin filament organization
F0007155biological_processcell adhesion
F0007160biological_processcell-matrix adhesion
F0007163biological_processestablishment or maintenance of cell polarity
F0007167biological_processenzyme-linked receptor protein signaling pathway
F0007186biological_processG protein-coupled receptor signaling pathway
F0007264biological_processsmall GTPase-mediated signal transduction
F0007411biological_processaxon guidance
F0008045biological_processmotor neuron axon guidance
F0008360biological_processregulation of cell shape
F0009611biological_processresponse to wounding
F0009653biological_processanatomical structure morphogenesis
F0010310biological_processregulation of hydrogen peroxide metabolic process
F0010591biological_processregulation of lamellipodium assembly
F0010592biological_processpositive regulation of lamellipodium assembly
F0010595biological_processpositive regulation of endothelial cell migration
F0010762biological_processregulation of fibroblast migration
F0010764biological_processnegative regulation of fibroblast migration
F0010810biological_processregulation of cell-substrate adhesion
F0010811biological_processpositive regulation of cell-substrate adhesion
F0014041biological_processregulation of neuron maturation
F0016020cellular_componentmembrane
F0016358biological_processdendrite development
F0016477biological_processcell migration
F0016601biological_processRac protein signal transduction
F0016787molecular_functionhydrolase activity
F0019899molecular_functionenzyme binding
F0019901molecular_functionprotein kinase binding
F0021799biological_processcerebral cortex radially oriented cell migration
F0021831biological_processembryonic olfactory bulb interneuron precursor migration
F0021894biological_processcerebral cortex GABAergic interneuron development
F0022604biological_processregulation of cell morphogenesis
F0030027cellular_componentlamellipodium
F0030031biological_processcell projection assembly
F0030032biological_processlamellipodium assembly
F0030036biological_processactin cytoskeleton organization
F0030041biological_processactin filament polymerization
F0030334biological_processregulation of cell migration
F0030425cellular_componentdendrite
F0030667cellular_componentsecretory granule membrane
F0030672cellular_componentsynaptic vesicle membrane
F0030742molecular_functionGTP-dependent protein binding
F0030838biological_processpositive regulation of actin filament polymerization
F0030865biological_processcortical cytoskeleton organization
F0030900biological_processforebrain development
F0031116biological_processpositive regulation of microtubule polymerization
F0031410cellular_componentcytoplasmic vesicle
F0031529biological_processruffle organization
F0031901cellular_componentearly endosome membrane
F0031996molecular_functionthioesterase binding
F0032496biological_processresponse to lipopolysaccharide
F0032587cellular_componentruffle membrane
F0032707biological_processnegative regulation of interleukin-23 production
F0032956biological_processregulation of actin cytoskeleton organization
F0034446biological_processsubstrate adhesion-dependent cell spreading
F0035025biological_processpositive regulation of Rho protein signal transduction
F0035556biological_processintracellular signal transduction
F0035567biological_processnon-canonical Wnt signaling pathway
F0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
F0036464cellular_componentcytoplasmic ribonucleoprotein granule
F0042470cellular_componentmelanosome
F0042554biological_processsuperoxide anion generation
F0042734cellular_componentpresynaptic membrane
F0042995cellular_componentcell projection
F0043020cellular_componentNADPH oxidase complex
F0043131biological_processerythrocyte enucleation
F0043652biological_processengulfment of apoptotic cell
F0044877molecular_functionprotein-containing complex binding
F0045202cellular_componentsynapse
F0045211cellular_componentpostsynaptic membrane
F0045216biological_processcell-cell junction organization
F0045428biological_processregulation of nitric oxide biosynthetic process
F0045730biological_processrespiratory burst
F0046425biological_processregulation of receptor signaling pathway via JAK-STAT
F0048012biological_processhepatocyte growth factor receptor signaling pathway
F0048168biological_processregulation of neuronal synaptic plasticity
F0048261biological_processnegative regulation of receptor-mediated endocytosis
F0048532biological_processanatomical structure arrangement
F0048812biological_processneuron projection morphogenesis
F0048813biological_processdendrite morphogenesis
F0048870biological_processcell motility
F0048873biological_processhomeostasis of number of cells within a tissue
F0051022molecular_functionRho GDP-dissociation inhibitor binding
F0051492biological_processregulation of stress fiber assembly
F0051496biological_processpositive regulation of stress fiber assembly
F0051668biological_processlocalization within membrane
F0051894biological_processpositive regulation of focal adhesion assembly
F0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0051932biological_processsynaptic transmission, GABAergic
F0055038cellular_componentrecycling endosome membrane
F0060071biological_processWnt signaling pathway, planar cell polarity pathway
F0060091cellular_componentkinocilium
F0060263biological_processregulation of respiratory burst
F0060326biological_processcell chemotaxis
F0060999biological_processpositive regulation of dendritic spine development
F0061344biological_processregulation of cell adhesion involved in heart morphogenesis
F0070062cellular_componentextracellular exosome
F0070376biological_processregulation of ERK5 cascade
F0071526biological_processsemaphorin-plexin signaling pathway
F0071542biological_processdopaminergic neuron differentiation
F0072659biological_processprotein localization to plasma membrane
F0086098biological_processangiotensin-activated signaling pathway involved in heart process
F0090023biological_processpositive regulation of neutrophil chemotaxis
F0090103biological_processcochlea morphogenesis
F0097178biological_processruffle assembly
F0098794cellular_componentpostsynapse
F0098978cellular_componentglutamatergic synapse
F0101003cellular_componentficolin-1-rich granule membrane
F0150052biological_processregulation of postsynapse assembly
F1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
F1900029biological_processpositive regulation of ruffle assembly
F1900242biological_processregulation of synaptic vesicle endocytosis
F1902622biological_processregulation of neutrophil migration
F1903348biological_processpositive regulation of bicellular tight junction assembly
F1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
F1904936biological_processinterneuron migration
F1904948biological_processmidbrain dopaminergic neuron differentiation
F2000386biological_processpositive regulation of ovarian follicle development
F2001222biological_processregulation of neuron migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8Q0N
ChainResidueDetails
CGLY12
ETYR720
CALA59
CLEU119
FGLY12
FALA59
FLEU119
ETYR216
ETYR395
ETYR511

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0000269|PubMed:38332367, ECO:0000269|PubMed:38355798, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:8Q0N, ECO:0007744|PDB:8WEJ
ChainResidueDetails
CALA13
FTHR17
FCYS18
FTHR35
FALA159
FLEU160
CLYS16
CTHR17
CCYS18
CTHR35
CALA159
CLEU160
FALA13
FLYS16

site_idSWS_FT_FI3
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:8Q0N
ChainResidueDetails
CVAL14
FGLU31
FTYR32
FPRO34
FLYS116
FASP118
CGLY15
CGLU31
CTYR32
CPRO34
CLYS116
CASP118
FVAL14
FGLY15

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
CGLY60
FGLY60
DSER1706
DSER1784

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:38355798, ECO:0007744|PDB:8WEJ
ChainResidueDetails
CSER158
FSER158

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
CTYR32
FTYR32

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
CTHR35
FTHR35

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
CSER71
FSER71

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
CCYS189
FCYS189

site_idSWS_FT_FI10
Number of Residues4
DetailsLIPID: (Microbial infection) N6-palmitoyl lysine => ECO:0000269|PubMed:29074776
ChainResidueDetails
CLYS183
CLYS184
FLYS183
FLYS184

site_idSWS_FT_FI11
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:1903399
ChainResidueDetails
CCYS189
FCYS189

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
CTYR32
FTYR32

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
CTHR35
FTHR35

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184, ECO:0000269|PubMed:38332367
ChainResidueDetails
CLYS147
FLYS147

site_idSWS_FT_FI15
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
CLYS166
FLYS166

237423

PDB entries from 2025-06-11

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