6UZK

Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6

Summary for 6UZK

Entry DOI	10.2210/pdb6uzk/pdb
Related	6OQ3 6OQ4
Descriptor	Krev interaction trapped protein 1, Ras-related protein Rap-1b, 2-hydroxy-6-methoxynaphthalene-1-carbaldehyde, ... (6 entities in total)
Functional Keywords	complex, small molecules, gtpase, krit1, cell adhesion
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	57141.56
Authors	Gingras, A.R. (deposition date: 2019-11-15, release date: 2020-11-18, Last modification date: 2023-10-11)
Primary citation	Lopez-Ramirez, M.A.,McCurdy, S.,Li, W.,Haynes, M.K.,Hale, P.,Francisco, K.,Oukoloff, K.,Bautista, M.,Choi, C.H.J.,Sun, H.,Gongol, B.,Shyy, J.Y.,Ballatore, C.,Sklar, L.A.,Gingras, A.R. Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. Faseb Bioadv, 3:334-355, 2021 Cited by PubMed: 33977234 DOI: 10.1096/fba.2020-00141 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.924 Å)

Structure validation