8HQ3

KL1 in complex with CRM1-Ran-RanBP1

Summary for 8HQ3

• Entry DOI: 10.2210/pdb8hq3/pdb
• Descriptor: GTP-binding nuclear protein Ran, methyl (3~{S},5~{R},6~{E},8~{Z},10~{R},12~{E},14~{E},16~{R})-3,16-bis(azanyl)-8,10,12-trimethyl-16-[(2~{S},4~{R},5~{S},6~{S})-5-methyl-4-oxidanyl-6-[(~{E})-prop-1-enyl]oxan-2-yl]-5-oxidanyl-hexadeca-6,8,12,14-tetraenoate, YRB1 isoform 1, ... (11 entities in total)
• Functional Keywords: nuclear export inhibitor, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 159185.42

Authors

Sun, Q.,Jian, L. (deposition date: 2022-12-13, release date: 2023-10-25)

• Primary citation: Jian, L.,Zscherp, R.,Beutling, U.,Shen, X.,Xu, S.,Zhang, X.,Bronstrup, M.,Klahn, P.,Sun, Q.; Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.; J.Med.Chem., 66:11940-11950, 2023; PubMed: 37595020; DOI: 10.1021/acs.jmedchem.3c00549

Experimental method

X-RAY DIFFRACTION (2.1 Å)