6V65

Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex

Summary for 6V65

• Entry DOI: 10.2210/pdb6v65/pdb
• Descriptor: Sprouty-related, EVH1 domain-containing protein 1, Neurofibromin, GTPase KRas, ... (8 entities in total)
• Functional Keywords: neurofibromin, ras, legius syndrome, rasgap, gap, spred, k-ras, evh1, grd, oncoprotein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 70548.72

Authors

Yan, W.,Simanshu, D.K. (deposition date: 2019-12-04, release date: 2020-07-15, Last modification date: 2023-10-11)

• Primary citation: Yan, W.,Markegard, E.,Dharmaiah, S.,Urisman, A.,Drew, M.,Esposito, D.,Scheffzek, K.,Nissley, D.V.,McCormick, F.,Simanshu, D.K.; Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.; Cell Rep, 32:107909-107909, 2020; PubMed: 32697994; DOI: 10.1016/j.celrep.2020.107909

Experimental method

X-RAY DIFFRACTION (2.763 Å)