6V65
Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex
Summary for 6V65
Entry DOI | 10.2210/pdb6v65/pdb |
Descriptor | Sprouty-related, EVH1 domain-containing protein 1, Neurofibromin, GTPase KRas, ... (8 entities in total) |
Functional Keywords | neurofibromin, ras, legius syndrome, rasgap, gap, spred, k-ras, evh1, grd, oncoprotein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 70548.72 |
Authors | Yan, W.,Simanshu, D.K. (deposition date: 2019-12-04, release date: 2020-07-15, Last modification date: 2023-10-11) |
Primary citation | Yan, W.,Markegard, E.,Dharmaiah, S.,Urisman, A.,Drew, M.,Esposito, D.,Scheffzek, K.,Nissley, D.V.,McCormick, F.,Simanshu, D.K. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep, 32:107909-107909, 2020 Cited by PubMed: 32697994DOI: 10.1016/j.celrep.2020.107909 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.763 Å) |
Structure validation
Download full validation report