6V65
Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sprouty-related, EVH1 domain-containing protein 1 | polymer | 113 | 12853.7 | 1 | UniProt (Q7Z699) Pfam (PF00568) | Homo sapiens (Human) | hSpred1 |
| 2 | B (B) | Neurofibromin | polymer | 329 | 37570.2 | 1 | UniProt (P21359) Pfam (PF00616) | Homo sapiens (Human) | Neurofibromatosis-related protein NF-1 |
| 3 | C (C) | GTPase KRas | polymer | 170 | 19328.8 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F, I, J (A, B, C) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 6 | G (C) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 7 | H (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 8 | K, L (B, C) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
B: 1203 - 1530 (UniProt: P21359)
C: 1 - 169 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 1202 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 69752.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 796.0 | |
| All* | Total formula weight | 70548.7 |
