8HQ6
KL2 in complex with CRM1-Ran-RanBP1
Summary for 8HQ6
Entry DOI | 10.2210/pdb8hq6/pdb |
Descriptor | GTP-binding nuclear protein Ran, DIMETHYL SULFOXIDE, methyl (3~{S},5~{R},6~{E},8~{Z},10~{R},12~{E},14~{E},16~{S})-3,16-bis(azanyl)-8,10,12-trimethyl-16-[(2~{S},4~{R},5~{S},6~{S})-5-methyl-4-oxidanyl-6-[(~{E})-prop-1-enyl]oxan-2-yl]-5-oxidanyl-hexadeca-6,8,12,14-tetraenoate, ... (12 entities in total) |
Functional Keywords | nuclear export inhibitor, transport protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 158855.50 |
Authors | |
Primary citation | Jian, L.,Zscherp, R.,Beutling, U.,Shen, X.,Xu, S.,Zhang, X.,Bronstrup, M.,Klahn, P.,Sun, Q. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66:11940-11950, 2023 Cited by PubMed: 37595020DOI: 10.1021/acs.jmedchem.3c00549 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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