7VIF
| Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIH
| Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | Descriptor: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7W6P
| Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist | Descriptor: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | Deposit date: | 2021-12-02 | Release date: | 2022-09-28 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
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7W7E
| Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist | Descriptor: | 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | Deposit date: | 2021-12-04 | Release date: | 2022-09-28 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
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7VFX
| The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, X.K, Chen, G, Liao, Q.W, Du, Y, Hu, H.L, Ye, D.Q. | Deposit date: | 2021-09-14 | Release date: | 2022-09-21 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nat Commun, 13, 2022
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7SRS
| 5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM) | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 2B, ... | Authors: | Barros-Alvarez, X, Cao, C, Panova, O, Roth, B.L, Skiniotis, G. | Deposit date: | 2021-11-08 | Release date: | 2022-09-21 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7SRQ
| 5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM) | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 2B | Authors: | Barros-Alvarez, X, Cao, C, Panova, O, Roth, B.L, Skiniotis, G. | Deposit date: | 2021-11-08 | Release date: | 2022-09-21 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7SRR
| 5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM) | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 2B, G protein subunit q (Gi2-mini-Gq chimera), ... | Authors: | Barros-Alvarez, X, Kim, K, Panova, O, Cao, C, Roth, B.L, Skiniotis, G. | Deposit date: | 2021-11-08 | Release date: | 2022-09-21 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110, 2022
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7X5H
| Serotonin 5A (5-HT5A) receptor-Gi protein complex | Descriptor: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Tan, Y, Xu, P, Huang, S, Xu, H.E, Jiang, Y. | Deposit date: | 2022-03-04 | Release date: | 2022-09-14 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the ligand binding and G i coupling of serotonin receptor 5-HT 5A . Cell Discov, 8, 2022
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7R0C
| Structure of the AVP-V2R-arrestin2-ScFv30 complex | Descriptor: | AVP, Arrestin2, ScFv30, ... | Authors: | Bous, J, Fouillen, A, Trapani, S, Granier, S, Mouillac, B, Bron, P. | Deposit date: | 2022-02-01 | Release date: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (4.73 Å) | Cite: | Structure of the vasopressin hormone-V2 receptor-beta-arrestin1 ternary complex. Sci Adv, 8, 2022
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8CU6
| Crystal structure of A2AAR-StaR2-S277-bRIL in complex with a novel A2a antagonist, LJ-4517 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol, Adenosine receptor A2a,Soluble cytochrome b562, ... | Authors: | Shiriaeva, A, Park, D.-J, Kim, G, Lee, Y, Hou, X, Jarhad, D.B, Kim, G, Yu, J, Hyun, Y.E, Kim, W, Gao, Z.-G, Jacobson, K.A, Han, G.W, Stevens, R.C, Jeong, L.S, Choi, S, Cherezov, V. | Deposit date: | 2022-05-16 | Release date: | 2022-08-31 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A 2A Adenosine Receptor. J.Med.Chem., 65, 2022
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8CU7
| Crystal structure of A2AAR-StaR2-bRIL in complex with a novel A2a antagonist, LJ-4517 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R,3R,4R)-2-[(8P)-6-amino-2-(hex-1-yn-1-yl)-8-(thiophen-2-yl)-9H-purin-9-yl]oxolane-3,4-diol, Adenosine receptor A2a,Soluble cytochrome b562, ... | Authors: | Shiriaeva, A, Park, D.-J, Kim, G, Lee, Y, Hou, X, Jarhad, D.B, Kim, G, Yu, J, Hyun, Y.E, Kim, W, Gao, Z.-G, Jacobson, K.A, Han, G.W, Stevens, R.C, Jeong, L.S, Choi, S, Cherezov, V. | Deposit date: | 2022-05-16 | Release date: | 2022-08-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A 2A Adenosine Receptor. J.Med.Chem., 65, 2022
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7X1U
| Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH. | Descriptor: | Endogenous Peptide Agonist TRH, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yang, F, Zhang, H.H, Meng, X.Y, Li, Y.G, Zhou, Y.X, Ling, S.L, Liu, L, Shi, P, Tian, C.L. | Deposit date: | 2022-02-24 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Res., 32, 2022
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7XAT
| Structure of somatostatin receptor 2 bound with SST14. | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | Deposit date: | 2022-03-19 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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7XAU
| Structure of somatostatin receptor 2 bound with octreotide. | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | Deposit date: | 2022-03-19 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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7XAV
| Structure of somatostatin receptor 2 bound with lanreotide. | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | Deposit date: | 2022-03-19 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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7X1T
| Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin. | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ScFv16, ... | Authors: | Yang, F, Zhang, H.H, Meng, X.Y, Li, Y.G, Zhou, Y.X, Ling, S.L, Liu, L, Shi, P, Tian, C.L. | Deposit date: | 2022-02-24 | Release date: | 2022-08-31 | Last modified: | 2022-09-14 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Res., 32, 2022
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7XA3
| Cryo-EM structure of the CCL2 bound CCR2-Gi complex | Descriptor: | C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | Deposit date: | 2022-03-17 | Release date: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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7X9Y
| Cryo-EM structure of the apo CCR3-Gi complex | Descriptor: | C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | Deposit date: | 2022-03-16 | Release date: | 2022-08-24 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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7XZ5
| GPR119-Gs-LPC complex | Descriptor: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-06-02 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XZ6
| GPR119-Gs-APD668 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-06-02 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nat.Struct.Mol.Biol., 29, 2022
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7XW5
| TSHR-thyroid stimulating hormone-Gs-ML109 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ... | Authors: | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | Deposit date: | 2022-05-26 | Release date: | 2022-08-24 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature, 609, 2022
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8DPG
| Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to psilocin | Descriptor: | 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2022-07-15 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40, 2022
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8DPI
| Cryo-EM structure of the 5HT2C receptor (VSV isoform) bound to lorcaserin | Descriptor: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2022-07-15 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40, 2022
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8DPF
| Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to lorcaserin | Descriptor: | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 5-hydroxytryptamine receptor 2C, Antibody fragment scFv16, ... | Authors: | Gumpper, R.H, Fay, J.F, Roth, B.L. | Deposit date: | 2022-07-15 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40, 2022
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