8DPF

Cryo-EM structure of the 5HT2C receptor (INI isoform) bound to lorcaserin

Summary for 8DPF

Entry DOI	10.2210/pdb8dpf/pdb
EMDB information	27633
Descriptor	5-hydroxytryptamine receptor 2C, G-alpha subunit q (Gi2-mini-Gq chimeric), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
Functional Keywords	gpcr, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	156491.39
Authors	Gumpper, R.H.,Fay, J.F.,Roth, B.L. (deposition date: 2022-07-15, release date: 2022-08-24, Last modification date: 2022-08-31)
Primary citation	Gumpper, R.H.,Fay, J.F.,Roth, B.L. Molecular insights into the regulation of constitutive activity by RNA editing of 5HT 2C serotonin receptors. Cell Rep, 40:111211-111211, 2022 Cited by PubMed: 35977511 DOI: 10.1016/j.celrep.2022.111211 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation