7W7E

Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist

Summary for 7W7E

• Entry DOI: 10.2210/pdb7w7e/pdb
• Related: 7W6P
• EMDB information: 32342
• Descriptor: Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, g-protein, signaling complex, biased agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 170153.12

Authors

Xu, J.,Fink, E.A.,Shoichet, B.K.,Du, Y. (deposition date: 2021-12-04, release date: 2022-09-28, Last modification date: 2022-10-12)

• Primary citation: Fink, E.A.,Xu, J.,Hubner, H.,Braz, J.M.,Seemann, P.,Avet, C.,Craik, V.,Weikert, D.,Schmidt, M.F.,Webb, C.M.,Tolmachova, N.A.,Moroz, Y.S.,Huang, X.P.,Kalyanaraman, C.,Gahbauer, S.,Chen, G.,Liu, Z.,Jacobson, M.P.,Irwin, J.J.,Bouvier, M.,Du, Y.,Shoichet, B.K.,Basbaum, A.I.,Gmeiner, P.; Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor.; Science, 377:eabn7065-eabn7065, 2022; PubMed: 36173843; DOI: 10.1126/science.abn7065

Experimental method

ELECTRON MICROSCOPY (3.4 Å)