7W6P
Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist
Summary for 7W6P
Entry DOI | 10.2210/pdb7w6p/pdb |
EMDB information | 32331 |
Descriptor | Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | gpcr, g-protein, signaling complex, biased agonist, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 170189.11 |
Authors | Xu, J.,Fink, E.A.,Shoichet, B.K.,Du, Y. (deposition date: 2021-12-02, release date: 2022-09-28, Last modification date: 2022-10-12) |
Primary citation | Fink, E.A.,Xu, J.,Hubner, H.,Braz, J.M.,Seemann, P.,Avet, C.,Craik, V.,Weikert, D.,Schmidt, M.F.,Webb, C.M.,Tolmachova, N.A.,Moroz, Y.S.,Huang, X.P.,Kalyanaraman, C.,Gahbauer, S.,Chen, G.,Liu, Z.,Jacobson, M.P.,Irwin, J.J.,Bouvier, M.,Du, Y.,Shoichet, B.K.,Basbaum, A.I.,Gmeiner, P. Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377:eabn7065-eabn7065, 2022 Cited by PubMed: 36173843DOI: 10.1126/science.abn7065 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.47 Å) |
Structure validation
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