7SRR

5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM)

Summary for 7SRR

• Entry DOI: 10.2210/pdb7srr/pdb
• EMDB information: 25402
• Descriptor: G protein subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: 5-ht2b receptor, serotonin receptor, g protein, gpcr, lysergic acid diethylamide, lsd, cryoem, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 145908.78

Authors

Barros-Alvarez, X.,Kim, K.,Panova, O.,Cao, C.,Roth, B.L.,Skiniotis, G. (deposition date: 2021-11-08, release date: 2022-09-21, Last modification date: 2022-10-19)

• Primary citation: Cao, C.,Barros-Alvarez, X.,Zhang, S.,Kim, K.,Damgen, M.A.,Panova, O.,Suomivuori, C.M.,Fay, J.F.,Zhong, X.,Krumm, B.E.,Gumpper, R.H.,Seven, A.B.,Robertson, M.J.,Krogan, N.J.,Huttenhain, R.,Nichols, D.E.,Dror, R.O.,Skiniotis, G.,Roth, B.L.; Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD.; Neuron, 110:3154-, 2022; PubMed: 36087581; DOI: 10.1016/j.neuron.2022.08.006

Experimental method

ELECTRON MICROSCOPY (2.9 Å)