7SRR
5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | G protein subunit q (Gi2-mini-Gq chimera) | polymer | 246 | 28084.8 | 1 | Homo sapiens | ||
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (E) | single-chain variable fragment 16 (scFv16) | polymer | 286 | 30552.2 | 1 | Homo sapiens | ||
| 5 | E (R) | 5-hydroxytryptamine receptor 2B | polymer | 370 | 41670.2 | 1 | UniProt (P41595) Pfam (PF00001) | Homo sapiens (Human) | 5-HT-2B,5-HT2B,Serotonin receptor 2B |
| 6 | F (R) | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide | non-polymer | 323.4 | 1 | Chemie (7LD) |
Sequence modifications
R: 36 - 405 (UniProt: P41595)
| PDB | External Database | Details |
|---|---|---|
| Trp 144 | Met 144 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 145585.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 323.4 | |
| All* | Total formula weight | 145908.8 |
