7SRR
5-HT2B receptor bound to LSD in complex with heterotrimeric mini-Gq protein obtained by cryo-electron microscopy (cryoEM)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0019001 | molecular_function | guanyl nucleotide binding |
| B | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| C | 0001750 | cellular_component | photoreceptor outer segment |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0005829 | cellular_component | cytosol |
| C | 0005834 | cellular_component | heterotrimeric G-protein complex |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007165 | biological_process | signal transduction |
| C | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| C | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| C | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| C | 0007213 | biological_process | G protein-coupled acetylcholine receptor signaling pathway |
| C | 0007265 | biological_process | Ras protein signal transduction |
| C | 0008283 | biological_process | cell population proliferation |
| C | 0016020 | cellular_component | membrane |
| C | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| C | 0044877 | molecular_function | protein-containing complex binding |
| C | 0045202 | cellular_component | synapse |
| C | 0050909 | biological_process | sensory perception of taste |
| C | 0051020 | molecular_function | GTPase binding |
| C | 0060041 | biological_process | retina development in camera-type eye |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| C | 0071870 | biological_process | cellular response to catecholamine stimulus |
| C | 0097381 | cellular_component | photoreceptor disc membrane |
| C | 1903561 | cellular_component | extracellular vesicle |
| D | 0005515 | molecular_function | protein binding |
| D | 0005834 | cellular_component | heterotrimeric G-protein complex |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0007165 | biological_process | signal transduction |
| D | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| D | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| D | 0016020 | cellular_component | membrane |
| D | 0031681 | molecular_function | G-protein beta-subunit binding |
| D | 0048144 | biological_process | fibroblast proliferation |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| D | 0071870 | biological_process | cellular response to catecholamine stimulus |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004993 | molecular_function | G protein-coupled serotonin receptor activity |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0006939 | biological_process | smooth muscle contraction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007507 | biological_process | heart development |
| R | 0016020 | cellular_component | membrane |
| R | 0042310 | biological_process | vasoconstriction |
| R | 0050795 | biological_process | regulation of behavior |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCAISVDRYIaI |
| Chain | Residue | Details |
| R | ALA141-ILE157 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| C | LEU70-SER84 | |
| C | ILE157-ILE171 | |
| C | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | ALA57-VAL79 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 113 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | SER80-ASN90 | |
| R | ASP152-THR171 | |
| R | THR240-LYS324 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | TYR91-LEU113 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | THR114-PRO129 | |
| R | LYS193-ASP216 | |
| R | THR346-MET360 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | ALA130-VAL151 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | ALA172-ILE192 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | PHE217-LEU239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | VAL325-ILE345 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | LEU361-LEU382 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23519215, ECO:0007744|PDB:4IB4, ECO:0007744|PDB:4NC3 |
| Chain | Residue | Details |
| R | ASP135 | |
| R | THR140 | |
| R | LEU209 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | LEU209 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| R | CYS397 |
