4IB4
Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine
Summary for 4IB4
Entry DOI | 10.2210/pdb4ib4/pdb |
Descriptor | Chimera protein of human 5-hydroxytryptamine receptor 2B and E. Coli soluble cytochrome b562, Ergotamine, PALMITIC ACID, ... (9 entities in total) |
Functional Keywords | ergotamine, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, signaling protein, electron transport, gpcr dock |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi- pass membrane protein : P41595 |
Total number of polymer chains | 1 |
Total formula weight | 51711.33 |
Authors | Wacker, D.,Wang, C.,Katritch, V.,Han, G.W.,Huang, X.,Vardy, E.,McCorvy, J.D.,Jiang, Y.,Chu, M.,Siu, F.Y.,Liu, W.,Xu, H.E.,Cherezov, V.,Roth, B.L.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2012-12-07, release date: 2013-03-13, Last modification date: 2023-09-20) |
Primary citation | Wacker, D.,Wang, C.,Katritch, V.,Han, G.W.,Huang, X.P.,Vardy, E.,McCorvy, J.D.,Jiang, Y.,Chu, M.,Siu, F.Y.,Liu, W.,Xu, H.E.,Cherezov, V.,Roth, B.L.,Stevens, R.C. Structural features for functional selectivity at serotonin receptors. Science, 340:615-619, 2013 Cited by PubMed: 23519215DOI: 10.1126/science.1232808 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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