7SRQ

5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM)

Summary for 7SRQ

Entry DOI	10.2210/pdb7srq/pdb
EMDB information	25401
Descriptor	5-hydroxytryptamine receptor 2B, 2-acetamido-2-deoxy-beta-D-glucopyranose, (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (3 entities in total)
Functional Keywords	5-ht2b receptor, serotonin receptor, gpcr, lysergic acid diethylamide, lsd, cryoem, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35597.27
Authors	Barros-Alvarez, X.,Cao, C.,Panova, O.,Roth, B.L.,Skiniotis, G. (deposition date: 2021-11-08, release date: 2022-09-21, Last modification date: 2022-10-19)
Primary citation	Cao, C.,Barros-Alvarez, X.,Zhang, S.,Kim, K.,Damgen, M.A.,Panova, O.,Suomivuori, C.M.,Fay, J.F.,Zhong, X.,Krumm, B.E.,Gumpper, R.H.,Seven, A.B.,Robertson, M.J.,Krogan, N.J.,Huttenhain, R.,Nichols, D.E.,Dror, R.O.,Skiniotis, G.,Roth, B.L. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110:3154-, 2022 Cited by PubMed: 36087581 DOI: 10.1016/j.neuron.2022.08.006 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation