7SRS

5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM)

Summary for 7SRS

Entry DOI	10.2210/pdb7srs/pdb
EMDB information	25403
Descriptor	Anti-5HT2BR Fab light chain, Anti-5HT2BR Fab heavy chain, 5-hydroxytryptamine receptor 2B, ... (8 entities in total)
Functional Keywords	5-ht2b receptor, serotonin receptor, beta-arrestin1, arrestin, gpcr, lysergic acid diethylamide, lsd, cryoem, membrane protein
Biological source	Mus musculus More
Total number of polymer chains	6
Total formula weight	150383.41
Authors	Barros-Alvarez, X.,Cao, C.,Panova, O.,Roth, B.L.,Skiniotis, G. (deposition date: 2021-11-08, release date: 2022-09-21, Last modification date: 2022-10-19)
Primary citation	Cao, C.,Barros-Alvarez, X.,Zhang, S.,Kim, K.,Damgen, M.A.,Panova, O.,Suomivuori, C.M.,Fay, J.F.,Zhong, X.,Krumm, B.E.,Gumpper, R.H.,Seven, A.B.,Robertson, M.J.,Krogan, N.J.,Huttenhain, R.,Nichols, D.E.,Dror, R.O.,Skiniotis, G.,Roth, B.L. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron, 110:3154-, 2022 Cited by PubMed: 36087581 DOI: 10.1016/j.neuron.2022.08.006 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation