7SRS
5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | P | Anti-5HT2BR Fab light chain | polymer | 209 | 22719.3 | 1 | Mus musculus | ||
| 2 | Q | Anti-5HT2BR Fab heavy chain | polymer | 218 | 23487.3 | 1 | Mus musculus | ||
| 3 | R | 5-hydroxytryptamine receptor 2B | polymer | 333 | 37722.5 | 1 | Pfam (PF00001) UniProt (by SIFTS) (P41595) In PDB | Homo sapiens (Human) | |
| 4 | C | Isoform 1B of Beta-arrestin-1 | polymer | 367 | 41345.3 | 1 | UniProt (P49407) Pfam (PF00339) Pfam (PF02752) In PDB | Homo sapiens (human) | Arrestin beta-1,Non-visual arrestin-2 |
| 5 | H | Fab30 heavy chain | polymer | 119 | 13063.5 | 1 | Mus musculus | ||
| 6 | L | Fab30 light chain | polymer | 106 | 11500.8 | 1 | Mus musculus | ||
| 7 | R | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | R | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide | non-polymer | 323.4 | 1 | Chemie (7LD) |
Sequence modifications
C: 2 - 368 (UniProt: P49407)
| PDB | External Database | Details |
|---|---|---|
| Glu 169 | Arg 169 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 149838.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 544.6 | |
| All* | Total formula weight | 150383.4 |
