7SRS
5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM)
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwHLCAISVDRYIaI |
| Chain | Residue | Details |
| R | ALA141-ILE157 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| P | TYR191-HIS197 | |
| Q | TYR201-HIS207 |
| site_id | PS00295 |
| Number of Residues | 19 |
| Details | ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL |
| Chain | Residue | Details |
| C | PHE61-LEU79 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | ALA57-VAL79 | |
| C | MET255 | |
| C | LYS324 | |
| C | LYS326 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 113 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | SER80-ASN90 | |
| R | ASP152-THR171 | |
| R | THR240-PHE383 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | TYR91-LEU113 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | THR114-PRO129 | |
| R | LYS193-ASP216 | |
| R | VAL442-SEP456 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | ALA130-VAL151 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | ALA172-ILE192 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | PHE217-LEU239 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | ASN384-SER441 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23519215, ECO:0007744|PDB:4IB4, ECO:0007744|PDB:4NC3 |
| Chain | Residue | Details |
| R | ASP135 | |
| R | THR140 | |
| R | LEU209 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538 |
| Chain | Residue | Details |
| R | LEU209 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
