7X1T

Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin.

Summary for 7X1T

• Entry DOI: 10.2210/pdb7x1t/pdb
• EMDB information: 32949
• Related PRD ID: PRD_002370
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Thyrotropin-releasing hormone receptor, mini-G alpha q protein, ... (6 entities in total)
• Functional Keywords: thyrotropin-releasing hormone receptor, cryo-em, protirelin, agonist, membrane protein
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 6
• Total formula weight: 145570.64

Authors

Yang, F.,Zhang, H.H.,Meng, X.Y.,Li, Y.G.,Zhou, Y.X.,Ling, S.L.,Liu, L.,Shi, P.,Tian, C.L. (deposition date: 2022-02-24, release date: 2022-08-31, Last modification date: 2024-10-23)

• Primary citation: Yang, F.,Zhang, H.,Meng, X.,Li, Y.,Zhou, Y.,Ling, S.,Sun, D.,Lv, P.,Liu, L.,Shi, P.,Tian, C.; Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue.; Cell Res., 32:858-861, 2022; PubMed: 35352031; DOI: 10.1038/s41422-022-00646-6

Experimental method

ELECTRON MICROSCOPY (3.26 Å)