7X1T
Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (F) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cattle) | G gamma-I |
| 2 | B (A) | Thyrotropin-releasing hormone receptor | polymer | 398 | 45119.7 | 1 | UniProt (P34981) Pfam (PF00001) | Homo sapiens (human) | TRH-R,Thyroliberin receptor |
| 3 | C (B) | mini-G alpha q protein | polymer | 246 | 28085.8 | 1 | Homo sapiens (human) | ||
| 4 | D (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62871) Pfam (PF00400) | Bos taurus (cattle) | Transducin beta chain 1 |
| 5 | E (D) | ScFv16 | polymer | 251 | 26679.7 | 1 | Rattus norvegicus (rat) | ||
| 6 | F (E) | Taltirelin | polymer | 5 | 423.4 | 1 | BIRD (PRD_002370) | synthetic construct |
Sequence modifications
F: 1 - 71 (UniProt: P63212)
A: 1 - 398 (UniProt: P34981)
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 87 | Ile 87 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 145570.6 | |
| All* | Total formula weight | 145570.6 |
