7VIF

Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P

Summary for 7VIF

Entry DOI	10.2210/pdb7vif/pdb
EMDB information	32007
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, scFv16, ... (6 entities in total)
Functional Keywords	gpcr, s1pr1, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	159113.68
Authors	Yu, L.Y.,Gan, B.,Xiao, Q.J.,Ren, R.B. (deposition date: 2021-09-26, release date: 2022-09-28, Last modification date: 2022-10-05)
Primary citation	Yu, L.,He, L.,Gan, B.,Ti, R.,Xiao, Q.,Hu, H.,Zhu, L.,Wang, S.,Ren, R. Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119:e2117716119-e2117716119, 2022 Cited by PubMed: 35412894 DOI: 10.1073/pnas.2117716119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.83 Å)

Structure validation