6XOX
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![BU of 6xox by Molmil](/molmil-images/mine/6xox) | cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 | Descriptor: | 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Glucagon-like peptide 1 receptor, ... | Authors: | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | Deposit date: | 2020-07-07 | Release date: | 2020-11-18 | Last modified: | 2020-12-09 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist. Proc.Natl.Acad.Sci.USA, 117, 2020
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6OIK
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![BU of 6oik by Molmil](/molmil-images/mine/6oik) | Muscarinic acetylcholine receptor 2-Go complex | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Antibody fragment, ... | Authors: | Maeda, S, Qianhui, Q, Skiniotis, G, Kobilka, B. | Deposit date: | 2019-04-09 | Release date: | 2019-05-08 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science, 364, 2019
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6E67
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![BU of 6e67 by Molmil](/molmil-images/mine/6e67) | Structure of beta2 adrenergic receptor fused to a Gs peptide | Descriptor: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera | Authors: | Liu, X, Xu, X, Hilger, D, Tiemann, J, Liu, H, Du, Y, Hirata, K, Sun, X, Guixa-Gonzalez, R, Mathiesen, J, Hildebrand, P, Kobilka, B. | Deposit date: | 2018-07-24 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural Insights into the Process of GPCR-G Protein Complex Formation. Cell, 177, 2019
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9BJK
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![BU of 9bjk by Molmil](/molmil-images/mine/9bjk) | Inactive mu opioid receptor bound to Nb6, naloxone and NAM | Descriptor: | Mu-type opioid receptor, Naloxone, Nalpha-[({(1M)-1-[5-(benzyloxy)pyridin-3-yl]naphthalen-2-yl}sulfanyl)acetyl]-3-methoxy-N,4-dimethyl-L-phenylalaninamide, ... | Authors: | O'Brien, E.S, Wang, H, Kaavya Krishna, K, Zhang, C, Kobilka, B.K. | Deposit date: | 2024-04-25 | Release date: | 2024-07-17 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | A mu-opioid receptor modulator that works cooperatively with naloxone. Nature, 631, 2024
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3KJ6
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![BU of 3kj6 by Molmil](/molmil-images/mine/3kj6) | Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex | Descriptor: | Beta-2 adrenergic receptor, Fab heavy chain, Fab light chain, ... | Authors: | Bokoch, M.P, Zou, Y, Rasmussen, S.G.F, Liu, C.W, Nygaard, R, Rosenbaum, D.M, Fung, J.J, Choi, H.-J, Thian, F.S, Kobilka, T.S, Puglisi, J.D, Weis, W.I, Pardo, L, Prosser, S, Mueller, L, Kobilka, B.K. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature, 463, 2010
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4DKL
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![BU of 4dkl by Molmil](/molmil-images/mine/4dkl) | Crystal structure of the mu-opioid receptor bound to a morphinan antagonist | Descriptor: | CHLORIDE ION, CHOLESTEROL, Mu-type opioid receptor, ... | Authors: | Manglik, A, Kruse, A.C, Kobilka, T.S, Thian, F.S, Mathiesen, J.M, Sunahara, R.K, Pardo, L, Weis, W.I, Kobilka, B.K, Granier, S. | Deposit date: | 2012-02-03 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist. Nature, 485, 2012
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7SBF
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![BU of 7sbf by Molmil](/molmil-images/mine/7sbf) | PZM21 bound Mu Opioid Receptor-Gi Protein Complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Huang, W, Qu, Q, Wang, H, Skiniotis, G, Kobilka, B. | Deposit date: | 2021-09-24 | Release date: | 2022-04-20 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists. Angew.Chem.Int.Ed.Engl., 61, 2022
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7SCG
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![BU of 7scg by Molmil](/molmil-images/mine/7scg) | FH210 bound Mu Opioid Receptor-Gi Protein Complex | Descriptor: | (2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, H, Kobilka, B. | Deposit date: | 2021-09-28 | Release date: | 2022-04-20 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists. Angew.Chem.Int.Ed.Engl., 61, 2022
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5VAI
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![BU of 5vai by Molmil](/molmil-images/mine/5vai) | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | Descriptor: | Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G. | Deposit date: | 2017-03-27 | Release date: | 2017-05-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature, 546, 2017
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5UIG
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![BU of 5uig by Molmil](/molmil-images/mine/5uig) | Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-amino-N-[(2-methoxyphenyl)methyl]-2-(3-methylphenyl)-2H-1,2,3-triazole-4-carboximidamide, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ... | Authors: | Sun, B, Bachhawat, P, Ling-Hon Chu, M, Ceska, T, Sands, Z, Lebon, F, Kobilka, T.S, Kobilka, B. | Deposit date: | 2017-01-13 | Release date: | 2017-02-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7JOZ
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![BU of 7joz by Molmil](/molmil-images/mine/7joz) | Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist | Descriptor: | 6-{4-[(furo[3,2-c]pyridin-4-yl)oxy]-2-methylphenyl}-1,5-dimethylpyrimidine-2,4(1H,3H)-dione, Endolysin,D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Sun, B, Feng, D, Chu, M.L, Fish, I, Kelm, S, Lebon, F, Lovera, S, Valade, A, Wood, M, Ceska, T, Kobilka, T.S, Sands, Z, Kobilka, B.K. | Deposit date: | 2020-08-07 | Release date: | 2021-04-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist. Nat Commun, 12, 2021
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2RH1
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![BU of 2rh1 by Molmil](/molmil-images/mine/2rh1) | High resolution crystal structure of human B2-adrenergic G protein-coupled receptor. | Descriptor: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, 1,4-BUTANEDIOL, ACETAMIDE, ... | Authors: | Cherezov, V, Rosenbaum, D.M, Hanson, M.A, Rasmussen, S.G.F, Thian, F.S, Kobilka, T.S, Choi, H.J, Kuhn, P, Weis, W.I, Kobilka, B.K, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR) | Deposit date: | 2007-10-05 | Release date: | 2007-10-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science, 318, 2007
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4MQT
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![BU of 4mqt by Molmil](/molmil-images/mine/4mqt) | Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and allosteric modulator LY2119620 | Descriptor: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, ... | Authors: | Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K. | Deposit date: | 2013-09-16 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature, 504, 2013
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3SN6
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![BU of 3sn6 by Molmil](/molmil-images/mine/3sn6) | Crystal structure of the beta2 adrenergic receptor-Gs protein complex | Descriptor: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Camelid antibody VHH fragment, Endolysin,Beta-2 adrenergic receptor, ... | Authors: | Rasmussen, S.G.F, DeVree, B.T, Zou, Y, Kruse, A.C, Chung, K.Y, Kobilka, T.S, Thian, F.S, Chae, P.S, Pardon, E, Calinski, D, Mathiesen, J.M, Shah, S.T.A, Lyons, J.A, Caffrey, M, Gellman, S.H, Steyaert, J, Skiniotis, G, Weis, W.I, Sunahara, R.K, Kobilka, B.K. | Deposit date: | 2011-06-28 | Release date: | 2011-07-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the beta2 adrenergic receptor-Gs protein complex Nature, 477, 2011
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3P0G
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![BU of 3p0g by Molmil](/molmil-images/mine/3p0g) | Structure of a nanobody-stabilized active state of the beta2 adrenoceptor | Descriptor: | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, Beta-2 adrenergic receptor, Lysozyme, ... | Authors: | Rasmussen, S.G.F, Choi, H.-J, Fung, J.J, Pardon, E, Casarosa, P, Chae, P.S, DeVree, B.T, Rosenbaum, D.M, Thian, F.S, Kobilka, T.S, Schnapp, A, Konetzki, I, Sunahara, R.K, Gellman, S.H, Pautsch, A, Steyaert, J, Weis, W.I, Kobilka, B.K. | Deposit date: | 2010-09-28 | Release date: | 2011-01-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of a nanobody-stabilized active state of the b2 adrenoceptor Nature, 469, 2011
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2R4S
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![BU of 2r4s by Molmil](/molmil-images/mine/2r4s) | Crystal structure of the human beta2 adrenoceptor | Descriptor: | Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, heavy chain, ... | Authors: | Rasmussen, S.G.F, Choi, H.J, Rosenbaum, D.M, Kobilka, T.S, Thian, F.S, Edwards, P.C, Burghammer, M, Ratnala, V.R, Sanishvili, R, Fischetti, R.F, Schertler, G.F, Weis, W.I, Kobilka, B.K. | Deposit date: | 2007-08-31 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature, 450, 2007
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4MQS
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![BU of 4mqs by Molmil](/molmil-images/mine/4mqs) | Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo | Descriptor: | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Muscarinic acetylcholine receptor M2, Nanobody 9-8 | Authors: | Kruse, A.C, Ring, A.M, Manglik, A, Hu, J, Hu, K, Eitel, K, Huebner, H, Pardon, E, Valant, C, Sexton, P.M, Christopoulos, A, Felder, C.C, Gmeiner, P, Steyaert, J, Weis, W.I, Garcia, K.C, Wess, J, Kobilka, B.K. | Deposit date: | 2013-09-16 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature, 504, 2013
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4EJ4
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![BU of 4ej4 by Molmil](/molmil-images/mine/4ej4) | Structure of the delta opioid receptor bound to naltrindole | Descriptor: | (4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol, Delta-type opioid receptor, Lysozyme chimera | Authors: | Granier, S, Manglik, A, Kruse, A.C, Kobilka, T.S, Thian, F.S, Weis, W.I, Kobilka, B.K. | Deposit date: | 2012-04-06 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure of the delta opioid receptor bound to naltrindole Nature, 485, 2012
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2R4R
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![BU of 2r4r by Molmil](/molmil-images/mine/2r4r) | Crystal structure of the human beta2 adrenoceptor | Descriptor: | Beta-2 adrenergic receptor, antibody for beta2 adrenoceptor, heavy chain, ... | Authors: | Rasmussen, S.G.F, Choi, H.J, Rosenbaum, D.M, Kobilka, T.S, Thian, F.S, Edwards, P.C, Burghammer, M, Ratnala, V.R, Sanishvili, R, Fischetti, R.F, Schertler, G.F, Weis, W.I, Kobilka, B.K. | Deposit date: | 2007-08-31 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature, 450, 2007
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7RGP
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![BU of 7rgp by Molmil](/molmil-images/mine/7rgp) | cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | Deposit date: | 2021-07-15 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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7YMJ
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![BU of 7ymj by Molmil](/molmil-images/mine/7ymj) | Cryo-EM structure of alpha1AAR-Nb6 complex bound to tamsulosin | Descriptor: | Nb6, Tamsulosin, alpha1A-adrenergic receptor | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-28 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YMH
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![BU of 7ymh by Molmil](/molmil-images/mine/7ymh) | Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to noradrenaline | Descriptor: | Nb29, Noradrenaline, alpha1A-adrenergic receptor, ... | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-28 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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7YM8
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![BU of 7ym8 by Molmil](/molmil-images/mine/7ym8) | Cryo-EM structure of Nb29-alpha1AAR-miniGsq complex bound to oxymetazoline | Descriptor: | CHOLESTEROL HEMISUCCINATE, Oxymetazoline, alpha1A adrenergic receptor, ... | Authors: | Toyoda, Y, Zhu, A, Yan, C, Kobilka, B.K, Liu, X. | Deposit date: | 2022-07-27 | Release date: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Structural basis of alpha 1A -adrenergic receptor activation and recognition by an extracellular nanobody. Nat Commun, 14, 2023
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6EG8
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![BU of 6eg8 by Molmil](/molmil-images/mine/6eg8) | Structure of the GDP-bound Gs heterotrimer | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Hilger, D, Liu, X, Aschauer, P, Kobilka, B.K. | Deposit date: | 2018-08-19 | Release date: | 2019-06-05 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Insights into the Process of GPCR-G Protein Complex Formation. Cell, 177, 2019
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7RBT
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![BU of 7rbt by Molmil](/molmil-images/mine/7rbt) | cryo-EM structure of human Gastric inhibitory polypeptide receptor GIPR bound to tirzepatide | Descriptor: | 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol, Gastric inhibitory polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. | Deposit date: | 2021-07-06 | Release date: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural determinants of dual incretin receptor agonism by tirzepatide. Proc.Natl.Acad.Sci.USA, 119, 2022
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