Structure of beta2 adrenergic receptor fused to a Gs peptide

Summary for 6E67

DescriptorBeta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one (2 entities in total)
Functional Keywordsg protein coupled receptor, membrane protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight121057.96
Primary citation
Liu, X.,Xu, X.,Hilger, D.,Aschauer, P.,Tiemann, J.K.S.,Du, Y.,Liu, H.,Hirata, K.,Sun, X.,Guixa-Gonzalez, R.,Mathiesen, J.M.,Hildebrand, P.W.,Kobilka, B.K.
Structural Insights into the Process of GPCR-G Protein Complex Formation.
Cell, 177:1243-1251.e12, 2019
PubMed: 31080070 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2019.04.021
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.31050 1.1% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution